Radiosensitization effect of poly(ADP‐ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation

Poly(ADP‐ribose) polymerase (PARP)‐1 promotes base excision repair and DNA strand break repair. Inhibitors of PARP enhance the cytotoxic effects of γ‐irradiation and X‐irradiation. We investigated the impact of PARP inhibition on the responses to γ‐irradiation (low liner energy transfer [LET] radiat...

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Veröffentlicht in:	Cancer science 2012-06, Vol.103 (6), p.1045-1050
Hauptverfasser:	Hirai, Takahisa, Shirai, Hidenori, Fujimori, Hiroaki, Okayasu, Ryuichi, Sasai, Keisuke, Masutani, Mitsuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Survival - drug effects Cell Survival - radiation effects DNA Damage - radiation effects DNA Repair - radiation effects Enzyme Inhibitors - pharmacology Gamma Rays Histones - biosynthesis Humans Linear Energy Transfer Original Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Neoplasms - radiotherapy Phosphorylation - radiation effects Phthalazines - pharmacology Piperazines - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Radiation-Sensitizing Agents S Phase Cell Cycle Checkpoints - radiation effects Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - metabolism
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