Nephrocytes are part of the spectrum of filtration epithelial diversity
The excretory system produces urine by ultrafiltration via a filtration epithelium. Podocytes are widely found as filtration epithelial cells in eucoelomates. In some animal taxa, including insects and crustaceans, nephrocytes serve to separate toxic substances from the body fluid, in addition to po...
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| Veröffentlicht in: | Cell and tissue research 2020-12, Vol.382 (3), p.609-625 |
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| creator | Miyaki, Takayuki Kawasaki, Yuto Matsumoto, Akira Kakuta, Soichiro Sakai, Tatsuo Ichimura, Koichiro |
| description | The excretory system produces urine by ultrafiltration via a filtration epithelium. Podocytes are widely found as filtration epithelial cells in eucoelomates. In some animal taxa, including insects and crustaceans, nephrocytes serve to separate toxic substances from the body fluid, in addition to podocytes.
Drosophila
nephrocytes have been recently utilized as a model system to study podocyte function and disease. However, functionality and cellular architecture are strikingly different between
Drosophila
nephrocytes and eucoelomate podocytes, and the phylogenetic relationship between these cells remains enigmatic. In this study, using focused-ion beam-scanning electron microscopy (FIB-SEM) tomography, we revealed three-dimensional architecture of decapod nephrocytes with unprecedented accuracy—they filled an enormous gap, which can be called “missing link,” in the evolutionary diversity of podocytes and nephrocytes. Thus, we concluded that nephrocytes are part of the spectrum of filtration epithelial diversity in animal phylogeny. |
| doi_str_mv | 10.1007/s00441-020-03313-7 |
| format | Article |
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Drosophila
nephrocytes have been recently utilized as a model system to study podocyte function and disease. However, functionality and cellular architecture are strikingly different between
Drosophila
nephrocytes and eucoelomate podocytes, and the phylogenetic relationship between these cells remains enigmatic. In this study, using focused-ion beam-scanning electron microscopy (FIB-SEM) tomography, we revealed three-dimensional architecture of decapod nephrocytes with unprecedented accuracy—they filled an enormous gap, which can be called “missing link,” in the evolutionary diversity of podocytes and nephrocytes. Thus, we concluded that nephrocytes are part of the spectrum of filtration epithelial diversity in animal phylogeny.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-020-03313-7</identifier><identifier>PMID: 33191456</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Drosophila ; Epithelial cells ; Epithelium ; Excretory system ; Human Genetics ; Insects ; Molecular Medicine ; Phylogeny ; Proteomics ; Regular ; Regular Article ; Scanning electron microscopy ; Ultrafiltration</subject><ispartof>Cell and tissue research, 2020-12, Vol.382 (3), p.609-625</ispartof><rights>The Author(s) 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-14152ff4195e81b2697926dc9c76afbd1171c1910aa3b1483c3c48d2972ed5df3</citedby><cites>FETCH-LOGICAL-c644t-14152ff4195e81b2697926dc9c76afbd1171c1910aa3b1483c3c48d2972ed5df3</cites><orcidid>0000-0001-6590-7912</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-020-03313-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-020-03313-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Miyaki, Takayuki</creatorcontrib><creatorcontrib>Kawasaki, Yuto</creatorcontrib><creatorcontrib>Matsumoto, Akira</creatorcontrib><creatorcontrib>Kakuta, Soichiro</creatorcontrib><creatorcontrib>Sakai, Tatsuo</creatorcontrib><creatorcontrib>Ichimura, Koichiro</creatorcontrib><title>Nephrocytes are part of the spectrum of filtration epithelial diversity</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><description>The excretory system produces urine by ultrafiltration via a filtration epithelium. Podocytes are widely found as filtration epithelial cells in eucoelomates. In some animal taxa, including insects and crustaceans, nephrocytes serve to separate toxic substances from the body fluid, in addition to podocytes.
Drosophila
nephrocytes have been recently utilized as a model system to study podocyte function and disease. However, functionality and cellular architecture are strikingly different between
Drosophila
nephrocytes and eucoelomate podocytes, and the phylogenetic relationship between these cells remains enigmatic. In this study, using focused-ion beam-scanning electron microscopy (FIB-SEM) tomography, we revealed three-dimensional architecture of decapod nephrocytes with unprecedented accuracy—they filled an enormous gap, which can be called “missing link,” in the evolutionary diversity of podocytes and nephrocytes. 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Podocytes are widely found as filtration epithelial cells in eucoelomates. In some animal taxa, including insects and crustaceans, nephrocytes serve to separate toxic substances from the body fluid, in addition to podocytes.
Drosophila
nephrocytes have been recently utilized as a model system to study podocyte function and disease. However, functionality and cellular architecture are strikingly different between
Drosophila
nephrocytes and eucoelomate podocytes, and the phylogenetic relationship between these cells remains enigmatic. In this study, using focused-ion beam-scanning electron microscopy (FIB-SEM) tomography, we revealed three-dimensional architecture of decapod nephrocytes with unprecedented accuracy—they filled an enormous gap, which can be called “missing link,” in the evolutionary diversity of podocytes and nephrocytes. Thus, we concluded that nephrocytes are part of the spectrum of filtration epithelial diversity in animal phylogeny.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33191456</pmid><doi>10.1007/s00441-020-03313-7</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-6590-7912</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Drosophila Epithelial cells Epithelium Excretory system Human Genetics Insects Molecular Medicine Phylogeny Proteomics Regular Regular Article Scanning electron microscopy Ultrafiltration |
| title | Nephrocytes are part of the spectrum of filtration epithelial diversity |
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