Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4

Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait and has been shown to exhibit a diverse range of pharmacological properties. The aim of the present study was to investigate the role of OMT in diabetic brain injury in vivo and in vitro. Diabetic...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-15
Hauptverfasser:	Tang, Jiayu, Zhang, Xi, Li, Xinliang, Huang, Yongpan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Apoptosis Apoptosis - drug effects Brain - enzymology Brain - pathology Coronary vessels Diabetes Diabetes Complications - drug therapy Diabetes Complications - enzymology Diabetes Complications - genetics Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - genetics Experiments Glucose Insulin Laboratory animals Male Memory Memory Disorders - drug therapy Memory Disorders - enzymology Memory Disorders - etiology Memory Disorders - genetics NADPH Oxidase 2 - genetics NADPH Oxidase 2 - metabolism NADPH Oxidase 4 - genetics NADPH Oxidase 4 - metabolism Oxidative stress Oxidative Stress - drug effects Plasma Quinolizines - pharmacology Rats Rats, Sprague-Dawley Reactive oxygen species Rodents Space exploration Traumatic brain injury
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