Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease or Charcot disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to death within 2–5 years of diagnosis, without any effective therapy available. Although the pathological mechanisms leading to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-29
Hauptverfasser:	Silva, Filomena S. G., Saso, Luciano, Firuzi, Omidreza, Mendes, Catarina, Montezinho, Liliana, Cunha-Oliveira, Teresa, Oliveira, Paulo J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Antioxidants Antioxidants - therapeutic use Dehydrogenases Disease Models, Animal Enzymes Humans Life expectancy Mitochondria Motor Neurons - metabolism Motor Neurons - pathology Mutation Neurodegeneration Neurons Neuroprotective Agents - therapeutic use Oxidative stress Oxidative Stress - drug effects Proteins Reactive oxygen species Review Risk factors Spinal cord
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!