Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases
Neurodegenerative diseases are devastating and incurable disorders characterized by neuronal dysfunction. The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases. This review will discuss an herba...
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| Veröffentlicht in: | BioMed research international 2020, Vol.2020 (2020), p.1-9 |
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| creator | Forouzanfar, Fatemeh Dabzadeh, Maryam Ghaddaripouri, Maryam Hajinejad, Mehrdad Sahab-Negah, Sajad |
| description | Neurodegenerative diseases are devastating and incurable disorders characterized by neuronal dysfunction. The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases. This review will discuss an herbal constituent known as cinnamaldehyde (CA) with the neuroprotective potential to treat neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Accumulating evidence supports the notion that CA displays neuroprotective effects in AD and PD animal models by modulating neuroinflammation, suppressing oxidative stress, and improving the synaptic connection. CA exerts these effects through its action on multiple signaling pathways, including TLR4/NF-κB, NLRP3, ERK1/2-MEK, NO, and Nrf2 pathways. To summarize, CA and its derivatives have been shown to improve pathological changes in AD and PD animal models, which may provide a new therapeutic option for neurodegenerative interventions. To this end, further experimental and clinical studies are required to prove the neuroprotective effects of CA and its derivatives. |
| doi_str_mv | 10.1155/2020/1034325 |
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The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases. This review will discuss an herbal constituent known as cinnamaldehyde (CA) with the neuroprotective potential to treat neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Accumulating evidence supports the notion that CA displays neuroprotective effects in AD and PD animal models by modulating neuroinflammation, suppressing oxidative stress, and improving the synaptic connection. CA exerts these effects through its action on multiple signaling pathways, including TLR4/NF-κB, NLRP3, ERK1/2-MEK, NO, and Nrf2 pathways. To summarize, CA and its derivatives have been shown to improve pathological changes in AD and PD animal models, which may provide a new therapeutic option for neurodegenerative interventions. To this end, further experimental and clinical studies are required to prove the neuroprotective effects of CA and its derivatives.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/1034325</identifier><identifier>PMID: 33274192</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acrolein - analogs & derivatives ; Acrolein - chemistry ; Acrolein - pharmacology ; Acrolein - therapeutic use ; Aldehydes ; Alzheimer's disease ; Animal models ; Animals ; Apoptosis ; Chemokines ; Cinnamaldehyde ; Cinnamon ; Cytochrome ; Cytokines ; Degeneration ; Derivatives ; Diabetic neuropathy ; Disease ; Disease Models, Animal ; Disease Progression ; Health aspects ; Humans ; Inflammation ; Inflammation - complications ; Inflammation - drug therapy ; Kinases ; Laboratories ; Ligands ; Movement disorders ; Natural products ; Nervous system ; Neurodegenerative diseases ; Neurodegenerative Diseases - complications ; Neurodegenerative Diseases - drug therapy ; Neurological disorders ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; NF-κB protein ; Nitric oxide ; Oxidative stress ; Parkinson's disease ; Pathogenesis ; Properties ; Proteins ; Review ; TLR4 protein ; Toll-like receptors ; Tumor necrosis factor-TNF</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-9</ispartof><rights>Copyright © 2020 Mehrdad Hajinejad et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Mehrdad Hajinejad et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Mehrdad Hajinejad et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-541e52895ddc85629bd9a27a5326ab68d5e9eba94cab5211e6916061d578909d3</citedby><cites>FETCH-LOGICAL-c499t-541e52895ddc85629bd9a27a5326ab68d5e9eba94cab5211e6916061d578909d3</cites><orcidid>0000-0002-2242-9794 ; 0000-0003-0023-6470</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683109/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683109/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33274192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Demarin, Vida</contributor><contributor>Vida Demarin</contributor><creatorcontrib>Forouzanfar, Fatemeh</creatorcontrib><creatorcontrib>Dabzadeh, Maryam</creatorcontrib><creatorcontrib>Ghaddaripouri, Maryam</creatorcontrib><creatorcontrib>Hajinejad, Mehrdad</creatorcontrib><creatorcontrib>Sahab-Negah, Sajad</creatorcontrib><title>Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Neurodegenerative diseases are devastating and incurable disorders characterized by neuronal dysfunction. The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases. This review will discuss an herbal constituent known as cinnamaldehyde (CA) with the neuroprotective potential to treat neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Accumulating evidence supports the notion that CA displays neuroprotective effects in AD and PD animal models by modulating neuroinflammation, suppressing oxidative stress, and improving the synaptic connection. CA exerts these effects through its action on multiple signaling pathways, including TLR4/NF-κB, NLRP3, ERK1/2-MEK, NO, and Nrf2 pathways. To summarize, CA and its derivatives have been shown to improve pathological changes in AD and PD animal models, which may provide a new therapeutic option for neurodegenerative interventions. To this end, further experimental and clinical studies are required to prove the neuroprotective effects of CA and its derivatives.</description><subject>Acrolein - analogs & derivatives</subject><subject>Acrolein - chemistry</subject><subject>Acrolein - pharmacology</subject><subject>Acrolein - therapeutic use</subject><subject>Aldehydes</subject><subject>Alzheimer's disease</subject><subject>Animal models</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Chemokines</subject><subject>Cinnamaldehyde</subject><subject>Cinnamon</subject><subject>Cytochrome</subject><subject>Cytokines</subject><subject>Degeneration</subject><subject>Derivatives</subject><subject>Diabetic neuropathy</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - drug therapy</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Ligands</subject><subject>Movement disorders</subject><subject>Natural products</subject><subject>Nervous system</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - complications</subject><subject>Neurodegenerative Diseases - drug therapy</subject><subject>Neurological disorders</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>NF-κB protein</subject><subject>Nitric oxide</subject><subject>Oxidative stress</subject><subject>Parkinson's disease</subject><subject>Pathogenesis</subject><subject>Properties</subject><subject>Proteins</subject><subject>Review</subject><subject>TLR4 protein</subject><subject>Toll-like receptors</subject><subject>Tumor necrosis factor-TNF</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1vEzEQxVcIRKvSG2e0EhekEuqx1971BSlK-ahUFQ5wtibrSeJq1y72bqr893hJSIETvtjS_Pxm3ryieAnsHYCUl5xxdglMVILLJ8UpF1DNFFTw9PgW4qQ4T-mO5dOAYlo9L06E4HUFmp8W_haHMWJXLpz32GNnabOzVKK35fWQyiuKbouD21Iq5z11LkQcqLylMQbnVx32PQ4h7sqvOGwecJdK5_dVS2vyFH_9La9cIkyUXhTPVtglOj_cZ8X3jx--LT7Pbr58ul7Mb2ZtpfUwkxWQ5I2W1raNVFwvrUZeoxRc4VI1VpKmJeqqxaXkAKR0tqbAyrrRTFtxVrzf696Py55sS37IJs19dD3GnQnozN8V7zZmHbamVo0AprPAm4NADD9GSoPpXWqp69BTGJPhlaoVZ3n9GX39D3oXxuizvYmSnNeihkdqjR2ZvLqQ-7aTqJkrXUNuKiett3uqjSGlSKvjyMDMlLiZEjeHxDP-6k-bR_h3vhm42AMb5y0-uP-Uo8zQCh9pECC0Ej8BcFm87A</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Forouzanfar, Fatemeh</creator><creator>Dabzadeh, Maryam</creator><creator>Ghaddaripouri, Maryam</creator><creator>Hajinejad, Mehrdad</creator><creator>Sahab-Negah, Sajad</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2242-9794</orcidid><orcidid>https://orcid.org/0000-0003-0023-6470</orcidid></search><sort><creationdate>2020</creationdate><title>Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases</title><author>Forouzanfar, Fatemeh ; Dabzadeh, Maryam ; Ghaddaripouri, Maryam ; Hajinejad, Mehrdad ; Sahab-Negah, Sajad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-541e52895ddc85629bd9a27a5326ab68d5e9eba94cab5211e6916061d578909d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acrolein - 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drug therapy</topic><topic>Neurological disorders</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>NF-κB protein</topic><topic>Nitric oxide</topic><topic>Oxidative stress</topic><topic>Parkinson's disease</topic><topic>Pathogenesis</topic><topic>Properties</topic><topic>Proteins</topic><topic>Review</topic><topic>TLR4 protein</topic><topic>Toll-like receptors</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forouzanfar, Fatemeh</creatorcontrib><creatorcontrib>Dabzadeh, Maryam</creatorcontrib><creatorcontrib>Ghaddaripouri, Maryam</creatorcontrib><creatorcontrib>Hajinejad, Mehrdad</creatorcontrib><creatorcontrib>Sahab-Negah, Sajad</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forouzanfar, Fatemeh</au><au>Dabzadeh, Maryam</au><au>Ghaddaripouri, Maryam</au><au>Hajinejad, Mehrdad</au><au>Sahab-Negah, Sajad</au><au>Demarin, Vida</au><au>Vida Demarin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Neurodegenerative diseases are devastating and incurable disorders characterized by neuronal dysfunction. The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases. This review will discuss an herbal constituent known as cinnamaldehyde (CA) with the neuroprotective potential to treat neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Accumulating evidence supports the notion that CA displays neuroprotective effects in AD and PD animal models by modulating neuroinflammation, suppressing oxidative stress, and improving the synaptic connection. CA exerts these effects through its action on multiple signaling pathways, including TLR4/NF-κB, NLRP3, ERK1/2-MEK, NO, and Nrf2 pathways. To summarize, CA and its derivatives have been shown to improve pathological changes in AD and PD animal models, which may provide a new therapeutic option for neurodegenerative interventions. To this end, further experimental and clinical studies are required to prove the neuroprotective effects of CA and its derivatives.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>33274192</pmid><doi>10.1155/2020/1034325</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2242-9794</orcidid><orcidid>https://orcid.org/0000-0003-0023-6470</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acrolein - analogs & derivatives Acrolein - chemistry Acrolein - pharmacology Acrolein - therapeutic use Aldehydes Alzheimer's disease Animal models Animals Apoptosis Chemokines Cinnamaldehyde Cinnamon Cytochrome Cytokines Degeneration Derivatives Diabetic neuropathy Disease Disease Models, Animal Disease Progression Health aspects Humans Inflammation Inflammation - complications Inflammation - drug therapy Kinases Laboratories Ligands Movement disorders Natural products Nervous system Neurodegenerative diseases Neurodegenerative Diseases - complications Neurodegenerative Diseases - drug therapy Neurological disorders Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-κB protein Nitric oxide Oxidative stress Parkinson's disease Pathogenesis Properties Proteins Review TLR4 protein Toll-like receptors Tumor necrosis factor-TNF |
| title | Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases |
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