PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study

OBJECTIVE:Arterial thrombosis leading to ischemic injury worsens the prognosis of many patients with cardiovascular disease. PZ-128 is a first-in-class pepducin that reversibly inhibits PAR1 (protease-activated receptor 1) on platelets and other vascular cells by targeting the intracellular surface...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2020-12, Vol.40 (12), p.2990-3003
Hauptverfasser:	Kuliopulos, Athan, Gurbel, Paul A., Rade, Jeffrey J., Kimmelstiel, Carey D., Turner, Susan E., Bliden, Kevin P., Fletcher, Elizabeth K., Cox, Daniel H., Covic, Lidija
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - diagnostic imaging Acute Coronary Syndrome - therapy Aged Blood Platelets - drug effects Blood Platelets - metabolism Cardiac Catheterization - adverse effects Cardiac Catheterization - instrumentation Cell-Penetrating Peptides - administration & dosage Cell-Penetrating Peptides - adverse effects Cell-Penetrating Peptides - pharmacokinetics Clinical and Population Studies Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - therapy Double-Blind Method Female Humans Infusions, Intravenous Lipopeptides - administration & dosage Lipopeptides - adverse effects Lipopeptides - pharmacokinetics Male Middle Aged Myocardium - pathology Necrosis Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - instrumentation Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - pharmacokinetics Proof of Concept Study Prospective Studies Receptor, PAR-1 - agonists Receptor, PAR-1 - metabolism Recurrence Stents Thrombosis - blood Thrombosis - etiology Thrombosis - prevention & control Time Factors Treatment Outcome United States
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