Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression

BACKGROUND Previous studies have implicated reduced brain-derived neurotrophic factor (BDNF) expression and BDNF-TrkB receptor signaling as well as microglial activation and neuroinflammation in poststroke depression (PSD). However, the contributions of microglial BDNF-TrkB signaling to PSD pathogen...

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Veröffentlicht in:	Medical science monitor 2020-11, Vol.26, p.e926323-e926323
Hauptverfasser:	Zhu, Han-Xiao, Cheng, Li-Jing, Ou Yang, Ri-Wei, Li, Yang-Yang, Liu, Jian, Dai, Dan, Wang, Wei, Yang, Ning, Li, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - metabolism Animal Study Animals Behavior, Animal Brain-Derived Neurotrophic Factor - metabolism CD11b Antigen - metabolism Depression - etiology Depression - metabolism Disease Models, Animal Injections, Intraventricular Microglia - metabolism Motor Activity Neuraminidase - metabolism Rats, Sprague-Dawley Receptor, trkB - metabolism Stroke - complications Tissue Plasminogen Activator - metabolism
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