SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia

Patients with chronic myeloid leukemia (CML) who are treated with tyrosine kinase inhibitors (TKIs) experience significant heterogeneity regarding depth and speed of responses. Factors intrinsic and extrinsic to CML cells contribute to response heterogeneity and TKI resistance. Among extrinsic facto...

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Veröffentlicht in:	Leukemia 2020-07, Vol.34 (7), p.1787-1798
Hauptverfasser:	Sinnakannu, Joanna R., Lee, Kian Leong, Cheng, Shanshan, Li, Jia, Yu, Mengge, Tan, Siew Peng, Ong, Clara Chong Hui, Li, Huihua, Than, Hein, Anczuków-Camarda, Olga, Krainer, Adrian R., Roca, Xavier, Rozen, Steven G., Iqbal, Jabed, Yang, Henry, Chuah, Charles, Ong, Sin Tiong
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/21 13/51 13/89 38 38/39 38/90 631/67/1990/283/1896 631/67/395 82 82/1 Antimitotic agents Antineoplastic agents B cells Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Bone marrow Bone Marrow - drug effects Bone Marrow - metabolism Bone Marrow - pathology Cancer Research Care and treatment CD34 antigen Chronic myeloid leukemia Critical Care Medicine Cytokines Cytokines - pharmacology Depletion Drug Resistance, Neoplasm - drug effects Gene Expression Regulation, Neoplastic Gene sequencing Hematology Hemopoiesis Heterogeneity Humans Imatinib Imatinib Mesylate - pharmacology Inhibitor drugs Intensive Internal Medicine Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Medicine Medicine & Public Health Myeloid leukemia Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Prognosis Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase Resistance factors Ribonucleic acid RNA Sensitivity Serine-Arginine Splicing Factors - genetics Serine-Arginine Splicing Factors - metabolism Splicing factors Targeted cancer therapy Tumor Cells, Cultured Tyrosine
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