Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer’s disease

Purpose The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer’s disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative with high affinity and selectivity for tau aggregates from human AD brain. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2020-12, Vol.47 (13), p.3176-3185
Hauptverfasser:	Schmidt, Mark E., Janssens, Luc, Moechars, Diederik, Rombouts, Frederik J. R., Timmers, Maarten, Barret, Olivier, Constantinescu, Cristian C., Madonia, Jennifer, Russell, David S., Sandiego, Christine M., Kolb, Hartmuth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aggregates Alzheimer Disease - diagnostic imaging Alzheimer's disease Amyloid Aniline Compounds Brain Brain - diagnostic imaging Brain - metabolism Cardiology Cerebellum Computed tomography Cortex (parietal) Digital video recorders Disease control Dosimeters Dosimetry Female Fluorine isotopes Fluorine Radioisotopes Humans Imaging Isoquinolines Kinetics Male Medicine Medicine & Public Health Neurodegenerative diseases Neurology Nuclear Medicine Occipital lobe Oncology Original Original Article Orthopedics Positron emission Positron emission tomography Pyridines Quantitation Radiology Radiopharmaceuticals Selectivity Tau protein tau Proteins - metabolism Temporal cortex Tomography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!