A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction

Background and Purpose Atherosclerosis, resulting from lipid dysregulation and vascular inflammation, causes atherosclerotic cardiovascular disease (ASCVD), which contributes to morbidity and mortality worldwide. Chalcone and its derivatives possess beneficial properties, including anti‐inflammatory...

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Veröffentlicht in:	British journal of pharmacology 2020-12, Vol.177 (23), p.5375-5392
Hauptverfasser:	Chen, Liv Weichien, Tsai, Min‐Chien, Chern, Ching‐Yuh, Tsao, Tien‐Ping, Lin, Feng‐Yen, Chen, Sy‐Jou, Tsui, Pi‐Fen, Liu, Yao‐Wen, Lu, Hsien‐Jui, Wu, Wan‐Lin, Lin, Wei‐Shiang, Tsai, Chien‐Sung, Lin, Chin‐Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Antioxidants Arteriosclerosis Atherogenesis Atherosclerosis ATP-binding protein Cardiovascular diseases Cell adhesion & migration Cell adhesion molecules Cholesterol Gene expression Heme oxygenase (decyclizing) High fat diet Inflammation Intercellular adhesion molecule 1 Labeling Low density lipoprotein Macrophages miRNA Morbidity mRNA Oxygenase Research Paper Risk factors Stat3 protein Tumor necrosis factor Western blotting
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