Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assay

•We evaluated a bead-based Luminex assay for the detection of SARS-CoV-2 antibodies.•A combination of the nucleocapsid protein and the receptor-binding domain results in a highly sensitive (96 %) and specific (99 %) assay that can detect positive cases at least five months after infection.•Because w...

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Veröffentlicht in:	Journal of virological methods 2021-02, Vol.288, p.114025-114025, Article 114025
Hauptverfasser:	Mariën, Joachim, Ceulemans, Ann, Michiels, Johan, Heyndrickx, Leo, Kerkhof, Karen, Foque, Nikki, Widdowson, Marc-Alain, Mortgat, Laure, Duysburgh, Els, Desombere, Isabelle, Jansens, Hilde, Van Esbroeck, Marjan, Ariën, Kevin K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing Antibodies, Viral - immunology Bead-based assay COVID-19 - diagnosis COVID-19 - immunology COVID-19 - virology Humans Immunoassay - methods Immunoassay - standards Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M - blood Immunoglobulin M - immunology Luminex antibody test Neutralization Tests Nucleocapsid Proteins - immunology ROC Curve Sars-CoV-2 SARS-CoV-2 - immunology Serosurveillance Spike Glycoprotein, Coronavirus - immunology Virus neutralization test
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