Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to progressive bone marrow (BM) fibrosis. Although the cellular mutations involved in the pathogenesis of PMF have been extensively investigated, the sequential events that drive stromal activation and fibrosis by hematopo...

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Veröffentlicht in:	Blood 2020-10, Vol.136 (18), p.2051-2064
Hauptverfasser:	Gleitz, Hélène F.E., Dugourd, Aurélien J.F., Leimkühler, Nils B., Snoeren, Inge A.M., Fuchs, Stijn N.R., Menzel, Sylvia, Ziegler, Susanne, Kröger, Nicolaus, Triviai, Ioanna, Büsche, Guntram, Kreipe, Hans, Banjanin, Bella, Pritchard, Jessica E., Hoogenboezem, Remco, Bindels, Eric M., Schumacher, Neele, Rose-John, Stefan, Elf, Shannon, Saez-Rodriguez, Julio, Kramann, Rafael, Schneider, Rebekka K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - immunology Bone Marrow - metabolism Bone Marrow - pathology Cell Proliferation Disease Progression Fibrosis - etiology Fibrosis - immunology Fibrosis - metabolism Fibrosis - pathology Humans Inflammation - etiology Inflammation - immunology Inflammation - metabolism Inflammation - pathology Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Male Megakaryocytes Mice Mice, Knockout Mutation Myeloid Neoplasia Myeloproliferative Disorders - complications Platelet Factor 4 - genetics Platelet Factor 4 - metabolism Primary Myelofibrosis - etiology Primary Myelofibrosis - immunology Primary Myelofibrosis - metabolism Primary Myelofibrosis - pathology
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