Validity of Sequential Organ Failure Assessment and Quick Sequential Organ Failure Assessment in Assessing Mortality Rate in the Intensive Care Unit With or Without Sepsis
Introduction Sepsis and septic shock (sepsis-induced hypotension not improved by adequate fluid resuscitation) are among the most common reasons for admission to an intensive care unit (ICU) and display high mortality rates. Different scoring systems are used to diagnose and predict the mortality of...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2020-10, Vol.12 (10), p.e11071-e11071 |
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| creator | Basham, Maleeha Ali Ghumro, Hassan Ali Muhammad Usman Shah, Syed Saeed, Sumayyah Pervez, Syed Annas Farooque, Umar Kumar, Naresh Imtiaz, Zainab Sajjad, Muhsana Jamal, Aisha Aslam Siddiqui, Iqra Idris, Farha |
| description | Introduction
Sepsis and septic shock (sepsis-induced hypotension not improved by adequate fluid resuscitation) are among the most common reasons for admission to an intensive care unit (ICU) and display high mortality rates. Different scoring systems are used to diagnose and predict the mortality of patients having sepsis. This study aims to validate the prognostic accuracy of Sequential Organ Failure Assessment (SOFA) and Quick Sequential Organ Failure Assessment (qSOFA) in determining the mortality of both septic and non-septic patients.
Materials and methods
This retrospective cohort study was conducted in May 2018 in the Surgical Intensive Care Unit (SICU) of a tertiary care hospital in Karachi, Pakistan. Past 200 patient records, from January 2018 to April 2018, were examined, and 20 records were discarded due to insufficient data. Sufficient observational data were collected, which was used to assess the validity of the SOFA and qSOFA in determining the mortality rate of sepsis. A comparison of the two modalities was made.
Results
Out of the 200 patients, 180 were enrolled. Data from their entire ICU stay were used to calculate their initial, highest, and mean SOFA and qSOFA. Mean SOFA score up to nine correlated with a mortality rate of up to |
| doi_str_mv | 10.7759/cureus.11071 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7676951</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2463602777</sourcerecordid><originalsourceid>FETCH-LOGICAL-c248t-60d6dde00dd0472e2ae461e2af42f4431e6ea42040f1465a40d182582457c7983</originalsourceid><addsrcrecordid>eNqNUU1PAyEUJEZjjXrzB3D0YCuwLGwvJk1j1URj_D4SXN626BYqsE38Tf5J0TZGb56Gl5k3E94gdEDJQMpyeFx3Abo4oJRIuoF2GBVVv6IV3_z17qH9GF8IIVnEiCTbqFcUjHEhyh308ahba2x6x77Bd_DWgUtWt_g6TLXDE23bnIBHMUKM88xh7Qy-6Wz9-i-1devJuim-8iHltJx1qxN8cWkG-MIlcNEuAY91Xn5wNuEnm2bYh2_0XcpRi2jjHtpqdBthf4276GFyej8-719en12MR5f9mvEq9QUxwhggxBjCJQOmgQuaoeGs4bygIEBzRjhpKBel5sTQipUV46Ws5bAqdtHJynfRPc_B1PkjQbdqEexch3fltVV_GWdnauqXSgophiXNBodrg-DzjWJScxtraFvtwHdR5dsXgjApZZYeraR18DEGaH5iKFFfFatVxeq74uITZ2uc4A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2463602777</pqid></control><display><type>article</type><title>Validity of Sequential Organ Failure Assessment and Quick Sequential Organ Failure Assessment in Assessing Mortality Rate in the Intensive Care Unit With or Without Sepsis</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Basham, Maleeha Ali ; Ghumro, Hassan Ali ; Muhammad Usman Shah, Syed ; Saeed, Sumayyah ; Pervez, Syed Annas ; Farooque, Umar ; Kumar, Naresh ; Imtiaz, Zainab ; Sajjad, Muhsana ; Jamal, Aisha ; Aslam Siddiqui, Iqra ; Idris, Farha</creator><creatorcontrib>Basham, Maleeha Ali ; Ghumro, Hassan Ali ; Muhammad Usman Shah, Syed ; Saeed, Sumayyah ; Pervez, Syed Annas ; Farooque, Umar ; Kumar, Naresh ; Imtiaz, Zainab ; Sajjad, Muhsana ; Jamal, Aisha ; Aslam Siddiqui, Iqra ; Idris, Farha</creatorcontrib><description>Introduction
Sepsis and septic shock (sepsis-induced hypotension not improved by adequate fluid resuscitation) are among the most common reasons for admission to an intensive care unit (ICU) and display high mortality rates. Different scoring systems are used to diagnose and predict the mortality of patients having sepsis. This study aims to validate the prognostic accuracy of Sequential Organ Failure Assessment (SOFA) and Quick Sequential Organ Failure Assessment (qSOFA) in determining the mortality of both septic and non-septic patients.
Materials and methods
This retrospective cohort study was conducted in May 2018 in the Surgical Intensive Care Unit (SICU) of a tertiary care hospital in Karachi, Pakistan. Past 200 patient records, from January 2018 to April 2018, were examined, and 20 records were discarded due to insufficient data. Sufficient observational data were collected, which was used to assess the validity of the SOFA and qSOFA in determining the mortality rate of sepsis. A comparison of the two modalities was made.
Results
Out of the 200 patients, 180 were enrolled. Data from their entire ICU stay were used to calculate their initial, highest, and mean SOFA and qSOFA. Mean SOFA score up to nine correlated with a mortality rate of up to <79%, while scores 10 and above predicted a 100% mortality rate. A mean qSOFA score of three predicted a 67% mortality rate. Univariate logistic analysis performed with odds ratio showed that the mean qSOFA score was in comparison more closely able to predict mortality, followed by mean SOFA score (p values < 0.01).
Conclusions
This study concluded that both SOFA and qSOFA scores are good predictors of mortality. However, qSOFA is more closely accurate in predicting mortality than SOFA. But further analysis with larger sample size for a longer duration as well as the application of these scores in the emergency departments and general wards can prove the precision of this study.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.11071</identifier><identifier>PMID: 33224665</identifier><language>eng</language><publisher>Palo Alto (CA): Cureus</publisher><subject>Anesthesiology ; Emergency Medicine ; Internal Medicine</subject><ispartof>Curēus (Palo Alto, CA), 2020-10, Vol.12 (10), p.e11071-e11071</ispartof><rights>Copyright © 2020, Basham et al. 2020 Basham et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c248t-60d6dde00dd0472e2ae461e2af42f4431e6ea42040f1465a40d182582457c7983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676951/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676951/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids></links><search><creatorcontrib>Basham, Maleeha Ali</creatorcontrib><creatorcontrib>Ghumro, Hassan Ali</creatorcontrib><creatorcontrib>Muhammad Usman Shah, Syed</creatorcontrib><creatorcontrib>Saeed, Sumayyah</creatorcontrib><creatorcontrib>Pervez, Syed Annas</creatorcontrib><creatorcontrib>Farooque, Umar</creatorcontrib><creatorcontrib>Kumar, Naresh</creatorcontrib><creatorcontrib>Imtiaz, Zainab</creatorcontrib><creatorcontrib>Sajjad, Muhsana</creatorcontrib><creatorcontrib>Jamal, Aisha</creatorcontrib><creatorcontrib>Aslam Siddiqui, Iqra</creatorcontrib><creatorcontrib>Idris, Farha</creatorcontrib><title>Validity of Sequential Organ Failure Assessment and Quick Sequential Organ Failure Assessment in Assessing Mortality Rate in the Intensive Care Unit With or Without Sepsis</title><title>Curēus (Palo Alto, CA)</title><description>Introduction
Sepsis and septic shock (sepsis-induced hypotension not improved by adequate fluid resuscitation) are among the most common reasons for admission to an intensive care unit (ICU) and display high mortality rates. Different scoring systems are used to diagnose and predict the mortality of patients having sepsis. This study aims to validate the prognostic accuracy of Sequential Organ Failure Assessment (SOFA) and Quick Sequential Organ Failure Assessment (qSOFA) in determining the mortality of both septic and non-septic patients.
Materials and methods
This retrospective cohort study was conducted in May 2018 in the Surgical Intensive Care Unit (SICU) of a tertiary care hospital in Karachi, Pakistan. Past 200 patient records, from January 2018 to April 2018, were examined, and 20 records were discarded due to insufficient data. Sufficient observational data were collected, which was used to assess the validity of the SOFA and qSOFA in determining the mortality rate of sepsis. A comparison of the two modalities was made.
Results
Out of the 200 patients, 180 were enrolled. Data from their entire ICU stay were used to calculate their initial, highest, and mean SOFA and qSOFA. Mean SOFA score up to nine correlated with a mortality rate of up to <79%, while scores 10 and above predicted a 100% mortality rate. A mean qSOFA score of three predicted a 67% mortality rate. Univariate logistic analysis performed with odds ratio showed that the mean qSOFA score was in comparison more closely able to predict mortality, followed by mean SOFA score (p values < 0.01).
Conclusions
This study concluded that both SOFA and qSOFA scores are good predictors of mortality. However, qSOFA is more closely accurate in predicting mortality than SOFA. But further analysis with larger sample size for a longer duration as well as the application of these scores in the emergency departments and general wards can prove the precision of this study.</description><subject>Anesthesiology</subject><subject>Emergency Medicine</subject><subject>Internal Medicine</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNUU1PAyEUJEZjjXrzB3D0YCuwLGwvJk1j1URj_D4SXN626BYqsE38Tf5J0TZGb56Gl5k3E94gdEDJQMpyeFx3Abo4oJRIuoF2GBVVv6IV3_z17qH9GF8IIVnEiCTbqFcUjHEhyh308ahba2x6x77Bd_DWgUtWt_g6TLXDE23bnIBHMUKM88xh7Qy-6Wz9-i-1devJuim-8iHltJx1qxN8cWkG-MIlcNEuAY91Xn5wNuEnm2bYh2_0XcpRi2jjHtpqdBthf4276GFyej8-719en12MR5f9mvEq9QUxwhggxBjCJQOmgQuaoeGs4bygIEBzRjhpKBel5sTQipUV46Ws5bAqdtHJynfRPc_B1PkjQbdqEexch3fltVV_GWdnauqXSgophiXNBodrg-DzjWJScxtraFvtwHdR5dsXgjApZZYeraR18DEGaH5iKFFfFatVxeq74uITZ2uc4A</recordid><startdate>20201020</startdate><enddate>20201020</enddate><creator>Basham, Maleeha Ali</creator><creator>Ghumro, Hassan Ali</creator><creator>Muhammad Usman Shah, Syed</creator><creator>Saeed, Sumayyah</creator><creator>Pervez, Syed Annas</creator><creator>Farooque, Umar</creator><creator>Kumar, Naresh</creator><creator>Imtiaz, Zainab</creator><creator>Sajjad, Muhsana</creator><creator>Jamal, Aisha</creator><creator>Aslam Siddiqui, Iqra</creator><creator>Idris, Farha</creator><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201020</creationdate><title>Validity of Sequential Organ Failure Assessment and Quick Sequential Organ Failure Assessment in Assessing Mortality Rate in the Intensive Care Unit With or Without Sepsis</title><author>Basham, Maleeha Ali ; Ghumro, Hassan Ali ; Muhammad Usman Shah, Syed ; Saeed, Sumayyah ; Pervez, Syed Annas ; Farooque, Umar ; Kumar, Naresh ; Imtiaz, Zainab ; Sajjad, Muhsana ; Jamal, Aisha ; Aslam Siddiqui, Iqra ; Idris, Farha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c248t-60d6dde00dd0472e2ae461e2af42f4431e6ea42040f1465a40d182582457c7983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anesthesiology</topic><topic>Emergency Medicine</topic><topic>Internal Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basham, Maleeha Ali</creatorcontrib><creatorcontrib>Ghumro, Hassan Ali</creatorcontrib><creatorcontrib>Muhammad Usman Shah, Syed</creatorcontrib><creatorcontrib>Saeed, Sumayyah</creatorcontrib><creatorcontrib>Pervez, Syed Annas</creatorcontrib><creatorcontrib>Farooque, Umar</creatorcontrib><creatorcontrib>Kumar, Naresh</creatorcontrib><creatorcontrib>Imtiaz, Zainab</creatorcontrib><creatorcontrib>Sajjad, Muhsana</creatorcontrib><creatorcontrib>Jamal, Aisha</creatorcontrib><creatorcontrib>Aslam Siddiqui, Iqra</creatorcontrib><creatorcontrib>Idris, Farha</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basham, Maleeha Ali</au><au>Ghumro, Hassan Ali</au><au>Muhammad Usman Shah, Syed</au><au>Saeed, Sumayyah</au><au>Pervez, Syed Annas</au><au>Farooque, Umar</au><au>Kumar, Naresh</au><au>Imtiaz, Zainab</au><au>Sajjad, Muhsana</au><au>Jamal, Aisha</au><au>Aslam Siddiqui, Iqra</au><au>Idris, Farha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validity of Sequential Organ Failure Assessment and Quick Sequential Organ Failure Assessment in Assessing Mortality Rate in the Intensive Care Unit With or Without Sepsis</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><date>2020-10-20</date><risdate>2020</risdate><volume>12</volume><issue>10</issue><spage>e11071</spage><epage>e11071</epage><pages>e11071-e11071</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Introduction
Sepsis and septic shock (sepsis-induced hypotension not improved by adequate fluid resuscitation) are among the most common reasons for admission to an intensive care unit (ICU) and display high mortality rates. Different scoring systems are used to diagnose and predict the mortality of patients having sepsis. This study aims to validate the prognostic accuracy of Sequential Organ Failure Assessment (SOFA) and Quick Sequential Organ Failure Assessment (qSOFA) in determining the mortality of both septic and non-septic patients.
Materials and methods
This retrospective cohort study was conducted in May 2018 in the Surgical Intensive Care Unit (SICU) of a tertiary care hospital in Karachi, Pakistan. Past 200 patient records, from January 2018 to April 2018, were examined, and 20 records were discarded due to insufficient data. Sufficient observational data were collected, which was used to assess the validity of the SOFA and qSOFA in determining the mortality rate of sepsis. A comparison of the two modalities was made.
Results
Out of the 200 patients, 180 were enrolled. Data from their entire ICU stay were used to calculate their initial, highest, and mean SOFA and qSOFA. Mean SOFA score up to nine correlated with a mortality rate of up to <79%, while scores 10 and above predicted a 100% mortality rate. A mean qSOFA score of three predicted a 67% mortality rate. Univariate logistic analysis performed with odds ratio showed that the mean qSOFA score was in comparison more closely able to predict mortality, followed by mean SOFA score (p values < 0.01).
Conclusions
This study concluded that both SOFA and qSOFA scores are good predictors of mortality. However, qSOFA is more closely accurate in predicting mortality than SOFA. But further analysis with larger sample size for a longer duration as well as the application of these scores in the emergency departments and general wards can prove the precision of this study.</abstract><cop>Palo Alto (CA)</cop><pub>Cureus</pub><pmid>33224665</pmid><doi>10.7759/cureus.11071</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesiology Emergency Medicine Internal Medicine |
| title | Validity of Sequential Organ Failure Assessment and Quick Sequential Organ Failure Assessment in Assessing Mortality Rate in the Intensive Care Unit With or Without Sepsis |
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