Endothelial sodium channel activation promotes cardiac stiffness and diastolic dysfunction in Western diet fed female mice

Obesity is associated with myocardial fibrosis and impaired diastolic relaxation, abnormalities that are especially prevalent in women. Normal coronary vascular endothelial function is integral in mediating diastolic relaxation, and recent work suggests increased activation of the endothelial cell (...

Ausführliche Beschreibung