The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre
To explore the clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke. A total of 2,474 COVID‐19 patients from February 10th to March 24th, 2020 were admitted and treated in two branches (Optic Valley and Sino‐French New City branch) of the Tongji Hospital. Data on the clin...
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| Veröffentlicht in: | The European journal of neuroscience 2021-02, Vol.53 (4), p.1350-1361 |
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| creator | Yao, Xiaolong Liu, Shengwen Wang, Junwen Zhao, Kai Long, Xiaobing He, Xuejun Kang, Huicong Yang, Yiping Ma, Xiaopeng Yue, Pengjie Shu, Kai Tang, Zhouping Lei, Ting Liu, Jihong Wang, Wei Zhang, Huaqiu |
| description | To explore the clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke. A total of 2,474 COVID‐19 patients from February 10th to March 24th, 2020 were admitted and treated in two branches (Optic Valley and Sino‐French New City branch) of the Tongji Hospital. Data on the clinical characteristics, laboratory parameters and prognosis of COVID‐19 patients with or without cerebral stroke were collected and comparatively analysed. Of the 2,474 COVID‐19 patients, 113 (4.7%) patients had cerebral stroke and 25 (1.0%) patients had new‐onset stroke. Eighty‐eight (77.9%) patients in the previous‐stroke group had cerebral ischaemia, while 25 (22.1%) patients in the new‐onset stroke group had cerebral ischaemia. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases than patients without stroke. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI, NT pro‐BNP and BUN. Consciousness disorders, a long disease course and poor prognosis were also more commonly observed in stroke patients. The mortality rate of stroke patients was almost double (12.4% vs. 6.9%) that of patients without stroke. In addition, age, male sex and hypertension were independent predictors for new cerebral stroke in COVID‐19 patients. In conclusion, the high risk of new‐onset stroke must be taken into consideration when treating COVID‐19 patients with an elderly age combined with a history of hypertension. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to an unfavourable outcome and higher mortality rate.
Of the 2,474 COVID‐19 patients in the Tongji Hospital, 113 (4.7%) patients had cerebral stroke, and 25 (1.0%) patients had new‐onset stroke. In 113 (4.7%) stroke patients, 88 (77.9%) patients in the previous‐stroke, while 25 (22.1%) patients in the new‐onset. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI. The mortality rate of stroke patients was almost double that of patients without stroke. In conclusion, COVID‐19 patients with an elderly age combined with a history of hypertension were more likely happening new‐onset stroke. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory |
| doi_str_mv | 10.1111/ejn.15007 |
| format | Article |
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Of the 2,474 COVID‐19 patients in the Tongji Hospital, 113 (4.7%) patients had cerebral stroke, and 25 (1.0%) patients had new‐onset stroke. In 113 (4.7%) stroke patients, 88 (77.9%) patients in the previous‐stroke, while 25 (22.1%) patients in the new‐onset. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI. The mortality rate of stroke patients was almost double that of patients without stroke. In conclusion, COVID‐19 patients with an elderly age combined with a history of hypertension were more likely happening new‐onset stroke. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to a higher mortality rate.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.15007</identifier><identifier>PMID: 33052619</identifier><language>eng</language><publisher>France: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Clinical and Translational Neuroscience ; clinical characteristics ; Comorbidity ; Coronary artery disease ; COVID-19 ; COVID-19 - complications ; COVID-19 - mortality ; Diabetes mellitus ; Female ; Heart diseases ; Humans ; Hypertension ; Hypertension - epidemiology ; Incidence ; Inflammation ; Ischemia ; Laboratories ; Male ; Middle Aged ; Mortality ; Patients ; Prognosis ; Research Report ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Stroke ; Stroke - complications ; Stroke - epidemiology</subject><ispartof>The European journal of neuroscience, 2021-02, Vol.53 (4), p.1350-1361</ispartof><rights>2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><rights>2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4717-7915236b011e291f9cc1ee160a621f3065cc0f15df457187ef1092335870d8613</citedby><cites>FETCH-LOGICAL-c4717-7915236b011e291f9cc1ee160a621f3065cc0f15df457187ef1092335870d8613</cites><orcidid>0000-0002-4419-990X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.15007$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.15007$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33052619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Xiaolong</creatorcontrib><creatorcontrib>Liu, Shengwen</creatorcontrib><creatorcontrib>Wang, Junwen</creatorcontrib><creatorcontrib>Zhao, Kai</creatorcontrib><creatorcontrib>Long, Xiaobing</creatorcontrib><creatorcontrib>He, Xuejun</creatorcontrib><creatorcontrib>Kang, Huicong</creatorcontrib><creatorcontrib>Yang, Yiping</creatorcontrib><creatorcontrib>Ma, Xiaopeng</creatorcontrib><creatorcontrib>Yue, Pengjie</creatorcontrib><creatorcontrib>Shu, Kai</creatorcontrib><creatorcontrib>Tang, Zhouping</creatorcontrib><creatorcontrib>Lei, Ting</creatorcontrib><creatorcontrib>Liu, Jihong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Zhang, Huaqiu</creatorcontrib><title>The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>To explore the clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke. A total of 2,474 COVID‐19 patients from February 10th to March 24th, 2020 were admitted and treated in two branches (Optic Valley and Sino‐French New City branch) of the Tongji Hospital. Data on the clinical characteristics, laboratory parameters and prognosis of COVID‐19 patients with or without cerebral stroke were collected and comparatively analysed. Of the 2,474 COVID‐19 patients, 113 (4.7%) patients had cerebral stroke and 25 (1.0%) patients had new‐onset stroke. Eighty‐eight (77.9%) patients in the previous‐stroke group had cerebral ischaemia, while 25 (22.1%) patients in the new‐onset stroke group had cerebral ischaemia. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases than patients without stroke. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI, NT pro‐BNP and BUN. Consciousness disorders, a long disease course and poor prognosis were also more commonly observed in stroke patients. The mortality rate of stroke patients was almost double (12.4% vs. 6.9%) that of patients without stroke. In addition, age, male sex and hypertension were independent predictors for new cerebral stroke in COVID‐19 patients. In conclusion, the high risk of new‐onset stroke must be taken into consideration when treating COVID‐19 patients with an elderly age combined with a history of hypertension. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to an unfavourable outcome and higher mortality rate.
Of the 2,474 COVID‐19 patients in the Tongji Hospital, 113 (4.7%) patients had cerebral stroke, and 25 (1.0%) patients had new‐onset stroke. In 113 (4.7%) stroke patients, 88 (77.9%) patients in the previous‐stroke, while 25 (22.1%) patients in the new‐onset. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI. The mortality rate of stroke patients was almost double that of patients without stroke. In conclusion, COVID‐19 patients with an elderly age combined with a history of hypertension were more likely happening new‐onset stroke. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to a higher mortality rate.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Clinical and Translational Neuroscience</subject><subject>clinical characteristics</subject><subject>Comorbidity</subject><subject>Coronary artery disease</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - mortality</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Incidence</subject><subject>Inflammation</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Research Report</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>SARS-CoV-2</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Stroke - epidemiology</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EokvhwAsgS1zgkNYTx3bCoVK1FCiq6KUgbpbXmex6ydrBTlrtjUdA4g15EtxuqQAJX2x5Pn2e8U_IU2AHkNchrv0BCMbUPTKDSrKiEbK-T2asEbyoQX7eI49SWjPGalmJh2SPcyZKCc2M_LhYIbW9886antqVicaOGF0anU3U-JYOMSx9SC7R0NH5-afT1z-_fYeGDmZ06MdEr9y4ohYjLmJWpDGGL_iKHtOI-ZgGtKO7xHw_tdtrBQCn1iRMtIthQ4PPNeeXPWatzcKIj8mDzvQJn9zu--Tjm5OL-bvi7Pzt6fz4rLCVAlWoBkTJ5YIBYNlA11gLiCCZkSV0nElhLetAtF0lFNQKO2BNybmoFWtrCXyfHO28w7TYYHvzuOn1EN3GxK0Oxum_K96t9DJcaiWVkKrKghe3ghi-TphGvXHJYt8bj2FKuqxEnlYoVWf0-T_oOkzR5_Ey1YDkVS15pl7uKJt_LkXs7poBpq-j1jlqfRN1Zp_92f0d-TvbDBzugCvX4_b_Jn3y_sNO-QtLt7VH</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Yao, Xiaolong</creator><creator>Liu, Shengwen</creator><creator>Wang, Junwen</creator><creator>Zhao, Kai</creator><creator>Long, Xiaobing</creator><creator>He, Xuejun</creator><creator>Kang, Huicong</creator><creator>Yang, Yiping</creator><creator>Ma, Xiaopeng</creator><creator>Yue, Pengjie</creator><creator>Shu, Kai</creator><creator>Tang, Zhouping</creator><creator>Lei, Ting</creator><creator>Liu, Jihong</creator><creator>Wang, Wei</creator><creator>Zhang, Huaqiu</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4419-990X</orcidid></search><sort><creationdate>202102</creationdate><title>The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre</title><author>Yao, Xiaolong ; Liu, Shengwen ; Wang, Junwen ; Zhao, Kai ; Long, Xiaobing ; He, Xuejun ; Kang, Huicong ; Yang, Yiping ; Ma, Xiaopeng ; Yue, Pengjie ; Shu, Kai ; Tang, Zhouping ; Lei, Ting ; Liu, Jihong ; Wang, Wei ; Zhang, Huaqiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4717-7915236b011e291f9cc1ee160a621f3065cc0f15df457187ef1092335870d8613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Clinical and Translational Neuroscience</topic><topic>clinical characteristics</topic><topic>Comorbidity</topic><topic>Coronary artery disease</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - mortality</topic><topic>Diabetes mellitus</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Incidence</topic><topic>Inflammation</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Research Report</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>SARS-CoV-2</topic><topic>Stroke</topic><topic>Stroke - complications</topic><topic>Stroke - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Xiaolong</creatorcontrib><creatorcontrib>Liu, Shengwen</creatorcontrib><creatorcontrib>Wang, Junwen</creatorcontrib><creatorcontrib>Zhao, Kai</creatorcontrib><creatorcontrib>Long, Xiaobing</creatorcontrib><creatorcontrib>He, Xuejun</creatorcontrib><creatorcontrib>Kang, Huicong</creatorcontrib><creatorcontrib>Yang, Yiping</creatorcontrib><creatorcontrib>Ma, Xiaopeng</creatorcontrib><creatorcontrib>Yue, Pengjie</creatorcontrib><creatorcontrib>Shu, Kai</creatorcontrib><creatorcontrib>Tang, Zhouping</creatorcontrib><creatorcontrib>Lei, Ting</creatorcontrib><creatorcontrib>Liu, Jihong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Zhang, Huaqiu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Xiaolong</au><au>Liu, Shengwen</au><au>Wang, Junwen</au><au>Zhao, Kai</au><au>Long, Xiaobing</au><au>He, Xuejun</au><au>Kang, Huicong</au><au>Yang, Yiping</au><au>Ma, Xiaopeng</au><au>Yue, Pengjie</au><au>Shu, Kai</au><au>Tang, Zhouping</au><au>Lei, Ting</au><au>Liu, Jihong</au><au>Wang, Wei</au><au>Zhang, Huaqiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2021-02</date><risdate>2021</risdate><volume>53</volume><issue>4</issue><spage>1350</spage><epage>1361</epage><pages>1350-1361</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>To explore the clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke. A total of 2,474 COVID‐19 patients from February 10th to March 24th, 2020 were admitted and treated in two branches (Optic Valley and Sino‐French New City branch) of the Tongji Hospital. Data on the clinical characteristics, laboratory parameters and prognosis of COVID‐19 patients with or without cerebral stroke were collected and comparatively analysed. Of the 2,474 COVID‐19 patients, 113 (4.7%) patients had cerebral stroke and 25 (1.0%) patients had new‐onset stroke. Eighty‐eight (77.9%) patients in the previous‐stroke group had cerebral ischaemia, while 25 (22.1%) patients in the new‐onset stroke group had cerebral ischaemia. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases than patients without stroke. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI, NT pro‐BNP and BUN. Consciousness disorders, a long disease course and poor prognosis were also more commonly observed in stroke patients. The mortality rate of stroke patients was almost double (12.4% vs. 6.9%) that of patients without stroke. In addition, age, male sex and hypertension were independent predictors for new cerebral stroke in COVID‐19 patients. In conclusion, the high risk of new‐onset stroke must be taken into consideration when treating COVID‐19 patients with an elderly age combined with a history of hypertension. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to an unfavourable outcome and higher mortality rate.
Of the 2,474 COVID‐19 patients in the Tongji Hospital, 113 (4.7%) patients had cerebral stroke, and 25 (1.0%) patients had new‐onset stroke. In 113 (4.7%) stroke patients, 88 (77.9%) patients in the previous‐stroke, while 25 (22.1%) patients in the new‐onset. Most COVID‐19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL‐6, cTnI. The mortality rate of stroke patients was almost double that of patients without stroke. In conclusion, COVID‐19 patients with an elderly age combined with a history of hypertension were more likely happening new‐onset stroke. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to a higher mortality rate.</abstract><cop>France</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33052619</pmid><doi>10.1111/ejn.15007</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4419-990X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Clinical and Translational Neuroscience clinical characteristics Comorbidity Coronary artery disease COVID-19 COVID-19 - complications COVID-19 - mortality Diabetes mellitus Female Heart diseases Humans Hypertension Hypertension - epidemiology Incidence Inflammation Ischemia Laboratories Male Middle Aged Mortality Patients Prognosis Research Report Retrospective Studies Risk Factors SARS-CoV-2 Stroke Stroke - complications Stroke - epidemiology |
| title | The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre |
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