Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive inflammation and respiratory disease, with cytokine storm and acute respiratory distress syndrome implicated in the most se...

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Veröffentlicht in:	Nature reviews cardiology 2021-03, Vol.18 (3), p.194-209
Hauptverfasser:	Gu, Sean X., Tyagi, Tarun, Jain, Kanika, Gu, Vivian W., Lee, Seung Hee, Hwa, Jonathan M., Kwan, Jennifer M., Krause, Diane S., Lee, Alfred I., Halene, Stephanie, Martin, Kathleen A., Chun, Hyung J., Hwa, John
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/256 631/326/596/4130 692/699/75/593/567 Administration, Inhalation Anticoagulants - therapeutic use Blood clot Blood clotting disorders Blood Coagulation Disorders - blood Blood Coagulation Disorders - drug therapy Blood Coagulation Disorders - etiology Blood Coagulation Disorders - physiopathology Blood Platelet Disorders - blood Blood Platelet Disorders - drug therapy Blood Platelet Disorders - etiology Blood Platelet Disorders - physiopathology Cardiac Imaging Cardiac Surgery Cardiology Care and treatment Coronaviruses COVID-19 COVID-19 - blood COVID-19 - complications COVID-19 - physiopathology COVID-19 Drug Treatment Development and progression Endothelium, Vascular - physiopathology Endothelium-Dependent Relaxing Factors - therapeutic use Epoprostenol - therapeutic use Heart Disease Risk Factors Humans Iloprost - therapeutic use Inflammation Inflammation - blood Inflammation - etiology Inflammation - physiopathology Medicine Medicine & Public Health Nitric Oxide - therapeutic use Pathogenesis Pathology Platelet Aggregation Inhibitors - therapeutic use Review Review Article Risk factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - drug therapy Systemic Inflammatory Response Syndrome - physiopathology Thrombosis Thrombosis - blood Thrombosis - etiology Thrombosis - immunology Thrombotic Microangiopathies - blood Thrombotic Microangiopathies - drug therapy Thrombotic Microangiopathies - etiology Thrombotic Microangiopathies - physiopathology Vascular Diseases - blood Vascular Diseases - drug therapy Vascular Diseases - etiology Vascular Diseases - physiopathology Vasodilator Agents - therapeutic use Venous Thromboembolism - blood Venous Thromboembolism - drug therapy Venous Thromboembolism - etiology Venous Thromboembolism - physiopathology
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