Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and s...
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| Veröffentlicht in: | Postȩpy dermatologii i alergologii 2020-01, Vol.37 (5), p.625-634 |
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| creator | Szczerkowska-Dobosz, Aneta Krasowska, Dorota Bartosińska, Joanna Stawczyk-Macieja, Marta Walczak, Aleksandra Owczarczyk-Saczonek, Agnieszka Reich, Adam Batycka-Baran, Aleksandra Czajkowski, Rafał Dobrucki, Iwona Dobrucki, Lawrence Górecka-Sokołowska, Magdalena Janaszak-Jasiecka, Anna Kalinowski, Leszek Nowicki, Roman Płoska, Agata Purzycka-Bohdan, Dorota Radulska, Adrianna Reszka, Edyta Samotij, Dominik Siekierzycka, Anna Slominski, Andrzej T. Slominski, Radomir M. Sobalska-Kwapis, Marta Strapagiel, Dominik Szczęch, Justyna Żmijewski, Michał Nedoszytko, Bogusław |
| description | Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and synovial tissues. Studies of the last two decades have changed the view of PsA from a mild, non-progressive arthritis to an inflammatory systemic disease with serious health consequences, not only associated with joint dysfunction, but also with an increased risk of cardiovascular disease and socioeconomic consequences with significantly reduced quality of life. The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome. |
| doi_str_mv | 10.5114/ada.2020.100478 |
| format | Article |
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| source | PubMed Central; PubMed Central Open Access |
| subjects | Review Paper |
| title | Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis |
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