Stereotactic body radiation therapy using CyberKnife for T1N0M0 lung cancer patients with severe pulmonary dysfunction
We retrospectively investigated the efficacy and safety of stereotactic body radiotherapy (SBRT) for T1N0M0 lung cancer using CyberKnife (CK) among 13 patients with severe pulmonary dysfunction which was defined as forced expiratory volume in 1 s (FEV1.0) of
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| Veröffentlicht in: | Journal of radiation research 2020-11, Vol.61 (6), p.903-907 |
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| container_title | Journal of radiation research |
| container_volume | 61 |
| creator | Abe, Takanori Ryuno, Yasuhiro Saito, Satoshi Aoshika, Tomomi Igari, Mitsunobu Hirai, Ryuta Kumazaki, Yu Kaira, Kyoichi Kagamu, Hiroshi Ishida, Hironori Noda, Shin-ei Kato, Shingo |
| description | We retrospectively investigated the efficacy and safety of stereotactic body radiotherapy (SBRT) for T1N0M0 lung cancer using CyberKnife (CK) among 13 patients with severe pulmonary dysfunction which was defined as forced expiratory volume in 1 s (FEV1.0) of |
| doi_str_mv | 10.1093/jrr/rraa075 |
| format | Article |
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The prescribed dose was 54 Gy in 3 fractions but adjusted for some patients if their tumors were in close proximity to the organs at risk (54 Gy/3 fractions: n = 11; 50 Gy/5 fractions: n = 1; 60 Gy/8 fractions: n = 1). During follow up (median follow-up: 27 months), we evaluated local control, overall survival and toxicity, using diagnostic imaging and laboratory tests. The patients’ median FEV1.0 was 0.84 L. Of the 13 patients, 3 were diagnosed as having lung cancer histologically and 10 diagnosed clinically. Their 2-year rates for overall survival and local control were 89 and 100%, respectively. So far, we have seen no adverse effects of grade 2 or higher. We concluded that CK-SBRT is effective and well tolerated for T1N0M0 lung cancer, even in patients with severe pulmonary dysfunction, but should be further evaluated with a larger cohort and longer follow-up periods.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1093/jrr/rraa075</identifier><identifier>PMID: 32880653</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Cancer patients ; Care and treatment ; Lung cancer ; Oncology/Medicine ; Radiation ; Radiotherapy</subject><ispartof>Journal of radiation research, 2020-11, Vol.61 (6), p.903-907</ispartof><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-eb72763b2ea4ecd6a4ad530eb63a2b70e6b60ec2f259f2ae3a2c5dc2857d5e463</citedby><cites>FETCH-LOGICAL-c449t-eb72763b2ea4ecd6a4ad530eb63a2b70e6b60ec2f259f2ae3a2c5dc2857d5e463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674703/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674703/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids></links><search><creatorcontrib>Abe, Takanori</creatorcontrib><creatorcontrib>Ryuno, Yasuhiro</creatorcontrib><creatorcontrib>Saito, Satoshi</creatorcontrib><creatorcontrib>Aoshika, Tomomi</creatorcontrib><creatorcontrib>Igari, Mitsunobu</creatorcontrib><creatorcontrib>Hirai, Ryuta</creatorcontrib><creatorcontrib>Kumazaki, Yu</creatorcontrib><creatorcontrib>Kaira, Kyoichi</creatorcontrib><creatorcontrib>Kagamu, Hiroshi</creatorcontrib><creatorcontrib>Ishida, Hironori</creatorcontrib><creatorcontrib>Noda, Shin-ei</creatorcontrib><creatorcontrib>Kato, Shingo</creatorcontrib><title>Stereotactic body radiation therapy using CyberKnife for T1N0M0 lung cancer patients with severe pulmonary dysfunction</title><title>Journal of radiation research</title><description>We retrospectively investigated the efficacy and safety of stereotactic body radiotherapy (SBRT) for T1N0M0 lung cancer using CyberKnife (CK) among 13 patients with severe pulmonary dysfunction which was defined as forced expiratory volume in 1 s (FEV1.0) of <1 L. The prescribed dose was 54 Gy in 3 fractions but adjusted for some patients if their tumors were in close proximity to the organs at risk (54 Gy/3 fractions: n = 11; 50 Gy/5 fractions: n = 1; 60 Gy/8 fractions: n = 1). During follow up (median follow-up: 27 months), we evaluated local control, overall survival and toxicity, using diagnostic imaging and laboratory tests. The patients’ median FEV1.0 was 0.84 L. Of the 13 patients, 3 were diagnosed as having lung cancer histologically and 10 diagnosed clinically. Their 2-year rates for overall survival and local control were 89 and 100%, respectively. So far, we have seen no adverse effects of grade 2 or higher. We concluded that CK-SBRT is effective and well tolerated for T1N0M0 lung cancer, even in patients with severe pulmonary dysfunction, but should be further evaluated with a larger cohort and longer follow-up periods.</description><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Lung cancer</subject><subject>Oncology/Medicine</subject><subject>Radiation</subject><subject>Radiotherapy</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptkU-LFDEQxYMo7rh68gsEPMrsViedZPoiLIP_cNWD6zmkk8pMlu6kSbpH-tubZRZhQXKoUPXejwePkLcNXDXQ8ev7nK9zNgaUeEY2DW-7bdcI9ZxsoK1_DhIuyKtS7gGYAgEvyQVnux1IwTfk9GvGjGk2dg6W9smtNBsXzBxSpPMRs5lWupQQD3S_9pi_xeCR-pTpXfMDvgMdlnqyJlrMdKo2jHOhf8J8pAVPFU2nZRhTNHmlbi1-ifYB_Zq88GYo-OZxXpLfnz7e7b9sb39-_rq_ud3aGn3eYq-YkrxnaFq0TprWOMEBe8kN6xWg7CWgZZ6JzjODdWuFs2wnlBPYSn5JPpy509KP6GxNl82gpxzGmkgnE_TTSwxHfUgnraRqFfAKeHcGHMyAOkSfqsyOoVh9I3dKMS5FV1VX_1HV53AMNkX0oe6fGN6fDTanUjL6f5Ea0A-t6tqqfmyV_wViZZiN</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Abe, Takanori</creator><creator>Ryuno, Yasuhiro</creator><creator>Saito, Satoshi</creator><creator>Aoshika, Tomomi</creator><creator>Igari, Mitsunobu</creator><creator>Hirai, Ryuta</creator><creator>Kumazaki, Yu</creator><creator>Kaira, Kyoichi</creator><creator>Kagamu, Hiroshi</creator><creator>Ishida, Hironori</creator><creator>Noda, Shin-ei</creator><creator>Kato, Shingo</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20201101</creationdate><title>Stereotactic body radiation therapy using CyberKnife for T1N0M0 lung cancer patients with severe pulmonary dysfunction</title><author>Abe, Takanori ; Ryuno, Yasuhiro ; Saito, Satoshi ; Aoshika, Tomomi ; Igari, Mitsunobu ; Hirai, Ryuta ; Kumazaki, Yu ; Kaira, Kyoichi ; Kagamu, Hiroshi ; Ishida, Hironori ; Noda, Shin-ei ; Kato, Shingo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-eb72763b2ea4ecd6a4ad530eb63a2b70e6b60ec2f259f2ae3a2c5dc2857d5e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Lung cancer</topic><topic>Oncology/Medicine</topic><topic>Radiation</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Takanori</creatorcontrib><creatorcontrib>Ryuno, Yasuhiro</creatorcontrib><creatorcontrib>Saito, Satoshi</creatorcontrib><creatorcontrib>Aoshika, Tomomi</creatorcontrib><creatorcontrib>Igari, Mitsunobu</creatorcontrib><creatorcontrib>Hirai, Ryuta</creatorcontrib><creatorcontrib>Kumazaki, Yu</creatorcontrib><creatorcontrib>Kaira, Kyoichi</creatorcontrib><creatorcontrib>Kagamu, Hiroshi</creatorcontrib><creatorcontrib>Ishida, Hironori</creatorcontrib><creatorcontrib>Noda, Shin-ei</creatorcontrib><creatorcontrib>Kato, Shingo</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Takanori</au><au>Ryuno, Yasuhiro</au><au>Saito, Satoshi</au><au>Aoshika, Tomomi</au><au>Igari, Mitsunobu</au><au>Hirai, Ryuta</au><au>Kumazaki, Yu</au><au>Kaira, Kyoichi</au><au>Kagamu, Hiroshi</au><au>Ishida, Hironori</au><au>Noda, Shin-ei</au><au>Kato, Shingo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereotactic body radiation therapy using CyberKnife for T1N0M0 lung cancer patients with severe pulmonary dysfunction</atitle><jtitle>Journal of radiation research</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>61</volume><issue>6</issue><spage>903</spage><epage>907</epage><pages>903-907</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>We retrospectively investigated the efficacy and safety of stereotactic body radiotherapy (SBRT) for T1N0M0 lung cancer using CyberKnife (CK) among 13 patients with severe pulmonary dysfunction which was defined as forced expiratory volume in 1 s (FEV1.0) of <1 L. The prescribed dose was 54 Gy in 3 fractions but adjusted for some patients if their tumors were in close proximity to the organs at risk (54 Gy/3 fractions: n = 11; 50 Gy/5 fractions: n = 1; 60 Gy/8 fractions: n = 1). During follow up (median follow-up: 27 months), we evaluated local control, overall survival and toxicity, using diagnostic imaging and laboratory tests. The patients’ median FEV1.0 was 0.84 L. Of the 13 patients, 3 were diagnosed as having lung cancer histologically and 10 diagnosed clinically. Their 2-year rates for overall survival and local control were 89 and 100%, respectively. So far, we have seen no adverse effects of grade 2 or higher. We concluded that CK-SBRT is effective and well tolerated for T1N0M0 lung cancer, even in patients with severe pulmonary dysfunction, but should be further evaluated with a larger cohort and longer follow-up periods.</abstract><pub>Oxford University Press</pub><pmid>32880653</pmid><doi>10.1093/jrr/rraa075</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Cancer patients Care and treatment Lung cancer Oncology/Medicine Radiation Radiotherapy |
| title | Stereotactic body radiation therapy using CyberKnife for T1N0M0 lung cancer patients with severe pulmonary dysfunction |
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