Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinf...

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Veröffentlicht in:	Science advances 2020-11, Vol.6 (46)
Hauptverfasser:	Nakano-Kobayashi, A, Fukumoto, A, Morizane, A, Nguyen, D T, Le, T M, Hashida, K, Hosoya, T, Takahashi, R, Takahashi, J, Hori, O, Hagiwara, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Dopaminergic Neurons - metabolism Mice Mice, Inbred C57BL Microglia - metabolism Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - therapy Neuroinflammatory Diseases Neuroscience NF-E2-Related Factor 2 - metabolism SciAdv r-articles
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