Role of hypoxia inducible factor-1 in cancer stem cells (Review)

Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth...

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Veröffentlicht in:	Molecular medicine reports 2021-01, Vol.23 (1), p.1-1
Hauptverfasser:	Zhang, Qi, Han, Zhenzhen, Zhu, Yanbo, Chen, Jingcheng, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding sites Biomarkers, Tumor - metabolism Breast cancer Cancer Cancer cells Carcinogenesis Cell adhesion & migration Cell cycle Cell growth Cell self-renewal Colorectal cancer Deoxyribonucleic acid DNA DNA methylation Epigenetics Epithelial-Mesenchymal Transition Ewings sarcoma Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1 - metabolism Kinases Liver cancer Lung cancer Medical prognosis Mesenchyme Metastases Metastasis MicroRNAs Neoplasms - metabolism Neoplastic Stem Cells - metabolism Non-coding RNA Phosphorylation Proteins Radiation therapy Review Stem cells Transcription factors Tumor Microenvironment
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