Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease
In a group of 208 patients with chronic ischaemic heart disease, the variation of A 2 -associated-LDL phosphatase (Lp-PLA 2 ) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA 2 can be accepted...
Gespeichert in:
| Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2021-01, Vol.36 (1), p.68-73 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 73 |
|---|---|
| container_issue | 1 |
| container_start_page | 68 |
| container_title | Journal of enzyme inhibition and medicinal chemistry |
| container_volume | 36 |
| creator | Diaconu, Adriana Coculescu, Bogdan-Ioan Manole, Gheorghe Vultur, Horațiu Coculescu, Elena Claudia Stocheci, Cristina Maria Tudorache, Ioan-Sorin Dincă, Alexandra-Ligia Dincă, Valeriu Gabi |
| description | In a group of 208 patients with chronic ischaemic heart disease, the variation of A
2
-associated-LDL phosphatase (Lp-PLA
2
) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA
2
can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy. |
| doi_str_mv | 10.1080/14756366.2020.1839447 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7671608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_739e169416cc4ced93fe3f74ef20427f</doaj_id><sourcerecordid>2460760279</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-490867e731d2fe25698f285a5c1fbd5c42317f004d32e6ade096ff2fa2403ca93</originalsourceid><addsrcrecordid>eNp9kstu1DAUhiMEoqXwCCAvyyLFt9jJBjGqKFSKBAtYWx77eOI2sYOdKeqCd6-HmY7ohoVl61y-8-v4r6q3BF8Q3OIPhMtGMCEuKKYl1LKOc_msOt3Fa8Ekf358C3FSvcr5BmNKKOEvqxPGSCu5IKfVn97PcU5xAR9qnXM0Xi9g0TzEXM7oZ50BrSg67-f6e7-i71GN5pizX4-ArNebEPPiDdLBouTzLVr7OOl0Cwn5gMyQYihZn82gYSqvAXRaSmOGAn5dvXB6zPDmcJ9VP68-_7j8WvffvlxfrvraNIwvNe9wKyRIRix1QBvRtY62jW4McWvbGE4ZkQ5jbhkFoS3gTjhHnaYcM6M7dlZd77k26hs1J18U3quovfobiGmjiipvRlCSdUBEx4kwhhuwHXPAnOTgKOZUusL6uGfN2_UE1kBYkh6fQJ9mgh_UJt4pKSQRuC2A8wMgxV9byIuaynpgHHWAuM2KcoGlwFTudDf7UpPKyhO44xiC1c4G6tEGamcDdbBB6Xv3r8Zj1-O_l4JP-wIfXEyT_h3TaNWi78eYXNLB-KzY_2c8ADobwyg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2460760279</pqid></control><display><type>article</type><title>Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease</title><source>Taylor & Francis Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Diaconu, Adriana ; Coculescu, Bogdan-Ioan ; Manole, Gheorghe ; Vultur, Horațiu ; Coculescu, Elena Claudia ; Stocheci, Cristina Maria ; Tudorache, Ioan-Sorin ; Dincă, Alexandra-Ligia ; Dincă, Valeriu Gabi</creator><creatorcontrib>Diaconu, Adriana ; Coculescu, Bogdan-Ioan ; Manole, Gheorghe ; Vultur, Horațiu ; Coculescu, Elena Claudia ; Stocheci, Cristina Maria ; Tudorache, Ioan-Sorin ; Dincă, Alexandra-Ligia ; Dincă, Valeriu Gabi</creatorcontrib><description>In a group of 208 patients with chronic ischaemic heart disease, the variation of A
2
-associated-LDL phosphatase (Lp-PLA
2
) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA
2
can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.</description><identifier>ISSN: 1475-6366</identifier><identifier>EISSN: 1475-6374</identifier><identifier>DOI: 10.1080/14756366.2020.1839447</identifier><identifier>PMID: 33187461</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>A2 phospholipase (PLA2); arachidonic acid (AA); chronic ischaemic heart disease; oxidative stress ; biomarker ; Research Paper</subject><ispartof>Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.68-73</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-490867e731d2fe25698f285a5c1fbd5c42317f004d32e6ade096ff2fa2403ca93</citedby><cites>FETCH-LOGICAL-c534t-490867e731d2fe25698f285a5c1fbd5c42317f004d32e6ade096ff2fa2403ca93</cites><orcidid>0000-0002-5375-272X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671608/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671608/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33187461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diaconu, Adriana</creatorcontrib><creatorcontrib>Coculescu, Bogdan-Ioan</creatorcontrib><creatorcontrib>Manole, Gheorghe</creatorcontrib><creatorcontrib>Vultur, Horațiu</creatorcontrib><creatorcontrib>Coculescu, Elena Claudia</creatorcontrib><creatorcontrib>Stocheci, Cristina Maria</creatorcontrib><creatorcontrib>Tudorache, Ioan-Sorin</creatorcontrib><creatorcontrib>Dincă, Alexandra-Ligia</creatorcontrib><creatorcontrib>Dincă, Valeriu Gabi</creatorcontrib><title>Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease</title><title>Journal of enzyme inhibition and medicinal chemistry</title><addtitle>J Enzyme Inhib Med Chem</addtitle><description>In a group of 208 patients with chronic ischaemic heart disease, the variation of A
2
-associated-LDL phosphatase (Lp-PLA
2
) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA
2
can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.</description><subject>A2 phospholipase (PLA2); arachidonic acid (AA); chronic ischaemic heart disease; oxidative stress</subject><subject>biomarker</subject><subject>Research Paper</subject><issn>1475-6366</issn><issn>1475-6374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>DOA</sourceid><recordid>eNp9kstu1DAUhiMEoqXwCCAvyyLFt9jJBjGqKFSKBAtYWx77eOI2sYOdKeqCd6-HmY7ohoVl61y-8-v4r6q3BF8Q3OIPhMtGMCEuKKYl1LKOc_msOt3Fa8Ekf358C3FSvcr5BmNKKOEvqxPGSCu5IKfVn97PcU5xAR9qnXM0Xi9g0TzEXM7oZ50BrSg67-f6e7-i71GN5pizX4-ArNebEPPiDdLBouTzLVr7OOl0Cwn5gMyQYihZn82gYSqvAXRaSmOGAn5dvXB6zPDmcJ9VP68-_7j8WvffvlxfrvraNIwvNe9wKyRIRix1QBvRtY62jW4McWvbGE4ZkQ5jbhkFoS3gTjhHnaYcM6M7dlZd77k26hs1J18U3quovfobiGmjiipvRlCSdUBEx4kwhhuwHXPAnOTgKOZUusL6uGfN2_UE1kBYkh6fQJ9mgh_UJt4pKSQRuC2A8wMgxV9byIuaynpgHHWAuM2KcoGlwFTudDf7UpPKyhO44xiC1c4G6tEGamcDdbBB6Xv3r8Zj1-O_l4JP-wIfXEyT_h3TaNWi78eYXNLB-KzY_2c8ADobwyg</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Diaconu, Adriana</creator><creator>Coculescu, Bogdan-Ioan</creator><creator>Manole, Gheorghe</creator><creator>Vultur, Horațiu</creator><creator>Coculescu, Elena Claudia</creator><creator>Stocheci, Cristina Maria</creator><creator>Tudorache, Ioan-Sorin</creator><creator>Dincă, Alexandra-Ligia</creator><creator>Dincă, Valeriu Gabi</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5375-272X</orcidid></search><sort><creationdate>20210101</creationdate><title>Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease</title><author>Diaconu, Adriana ; Coculescu, Bogdan-Ioan ; Manole, Gheorghe ; Vultur, Horațiu ; Coculescu, Elena Claudia ; Stocheci, Cristina Maria ; Tudorache, Ioan-Sorin ; Dincă, Alexandra-Ligia ; Dincă, Valeriu Gabi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-490867e731d2fe25698f285a5c1fbd5c42317f004d32e6ade096ff2fa2403ca93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>A2 phospholipase (PLA2); arachidonic acid (AA); chronic ischaemic heart disease; oxidative stress</topic><topic>biomarker</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diaconu, Adriana</creatorcontrib><creatorcontrib>Coculescu, Bogdan-Ioan</creatorcontrib><creatorcontrib>Manole, Gheorghe</creatorcontrib><creatorcontrib>Vultur, Horațiu</creatorcontrib><creatorcontrib>Coculescu, Elena Claudia</creatorcontrib><creatorcontrib>Stocheci, Cristina Maria</creatorcontrib><creatorcontrib>Tudorache, Ioan-Sorin</creatorcontrib><creatorcontrib>Dincă, Alexandra-Ligia</creatorcontrib><creatorcontrib>Dincă, Valeriu Gabi</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diaconu, Adriana</au><au>Coculescu, Bogdan-Ioan</au><au>Manole, Gheorghe</au><au>Vultur, Horațiu</au><au>Coculescu, Elena Claudia</au><au>Stocheci, Cristina Maria</au><au>Tudorache, Ioan-Sorin</au><au>Dincă, Alexandra-Ligia</au><au>Dincă, Valeriu Gabi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease</atitle><jtitle>Journal of enzyme inhibition and medicinal chemistry</jtitle><addtitle>J Enzyme Inhib Med Chem</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>36</volume><issue>1</issue><spage>68</spage><epage>73</epage><pages>68-73</pages><issn>1475-6366</issn><eissn>1475-6374</eissn><abstract>In a group of 208 patients with chronic ischaemic heart disease, the variation of A
2
-associated-LDL phosphatase (Lp-PLA
2
) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA
2
can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>33187461</pmid><doi>10.1080/14756366.2020.1839447</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5375-272X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1475-6366 |
| ispartof | Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.68-73 |
| issn | 1475-6366 1475-6374 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7671608 |
| source | Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | A2 phospholipase (PLA2) arachidonic acid (AA) chronic ischaemic heart disease oxidative stress biomarker Research Paper |
| title | Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T09%3A44%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lipoprotein-associated%20phospholipase%20A2%20(Lp-PLA2)%20-%20possible%20diagnostic%20and%20risk%20biomarker%20in%20chronic%20ischaemic%20heart%20disease&rft.jtitle=Journal%20of%20enzyme%20inhibition%20and%20medicinal%20chemistry&rft.au=Diaconu,%20Adriana&rft.date=2021-01-01&rft.volume=36&rft.issue=1&rft.spage=68&rft.epage=73&rft.pages=68-73&rft.issn=1475-6366&rft.eissn=1475-6374&rft_id=info:doi/10.1080/14756366.2020.1839447&rft_dat=%3Cproquest_pubme%3E2460760279%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2460760279&rft_id=info:pmid/33187461&rft_doaj_id=oai_doaj_org_article_739e169416cc4ced93fe3f74ef20427f&rfr_iscdi=true |