Biochemical analysis of TOPBP1 oligomerization

•The ATR activator TOPBP1 oligomerizes via BRCT-BRCT domain interactions.•TOPBP1 oligomers can still bind heterologous binding partners.•The TOPBP1 AAD activates ATR as a tetramer. TOPBP1 is an important scaffold protein that helps orchestrate the cellular response to DNA damage. Although it has bee...

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Veröffentlicht in:	DNA repair 2020-12, Vol.96, p.102973-102973, Article 102973
Hauptverfasser:	Kim, Ahhyun, Montales, Katrina, Ruis, Kenna, Senebandith, Holly, Gasparyan, Hovik, Cowan, Quinn, Michael, W. Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins - metabolism ATR BRCT Cell Cycle Proteins - metabolism Checkpoint DNA Damage DNA-Binding Proteins - metabolism Protein Interaction Domains and Motifs Protein Multimerization Scaffold Signal Transduction Xenopus - genetics Xenopus - metabolism
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