Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner

Propionate has been reported to exert antidepressant effects, but high-dose propionate may induce autism-like symptoms in experimental animals through induction of dysbiosis of neurotransmitters. The bi-directional effects of propionate seem to be dose-dependent. However, due to the pathological dis...

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Veröffentlicht in:	Scientific reports 2020-11, Vol.10 (1), p.19917, Article 19917
Hauptverfasser:	Hao, Chunyan, Gao, Zefeng, Liu, XianJun, Rong, Zhijiang, Jia, Jingjing, Kang, Kaiqi, Guo, Weiwei, Li, Jianguo
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/1426 692/308/153 692/699/375 Acids Administration, Intravenous Animals Antidepressants Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Autism Behavior, Animal Body weight Depression - drug therapy Dihydroxyphenylacetic acid Disease Models, Animal Dopamine Dose-Response Relationship, Drug Dysbacteriosis Food additives Hippocampus Homovanillic acid Humanities and Social Sciences Intravenous administration Male Mental depression Metabolic disorders Metabolomics Mood multidisciplinary Neurotransmitters Norepinephrine Propionates - administration & dosage Propionates - pharmacology Propionic acid Rats Rats, Sprague-Dawley Reinforcement Science Science (multidisciplinary) Serotonin Sodium propionate Stress, Psychological - prevention & control Toxicity Tryptophan γ-Aminobutyric acid
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