HIV-Associated “Double-Hit” Lymphoma of the Tonsil: A First Reported Case
Double-hit lymphoma (DHL) is a unique subtype of non-Hodgkin lymphoma characterized by atleast two rearrangements involving MYC, BLC2 , and/or BCL6 . These lymphomas are uncommon and aggressive, responding poorly to typical chemotherapy regimens. Lymphomas rarely arise from the oral cavity or tonsil...
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| Veröffentlicht in: | Head & neck pathology (Totowa, N.J.) N.J.), 2020-12, Vol.14 (4), p.1129-1133 |
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| container_title | Head & neck pathology (Totowa, N.J.) |
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| creator | Hinkle, Chad Makar, Gabriel S. Brody, Joshua D. Ahmad, Nadir Zhu, Gord Guo |
| description | Double-hit lymphoma (DHL) is a unique subtype of non-Hodgkin lymphoma characterized by atleast two rearrangements involving
MYC, BLC2
, and/or
BCL6
. These lymphomas are uncommon and aggressive, responding poorly to typical chemotherapy regimens. Lymphomas rarely arise from the oral cavity or tonsils, and those presenting as a neck mass are predominantly diffuse large B-cell lymphoma. To date, primary DHL of the tonsils has yet to be described in the literature. Here, we report a case of a 44 year-old male patient with well-controlled human immunodeficiency virus (HIV) who presented with a sore throat. He subsequently developed acute respiratory compromise due to a rapidly enlarging tonsillar mass. Pathologic and genetic analysis confirmed the presence of
BCL6
and
MYC
rearrangements suggestive of DHL of the tonsils. In a young patient with HIV and a neck mass, it is essential that lymphoma remains on the list of differential diagnoses as prompt diagnosis and treatment may prevent complications from its rapid expansion. |
| doi_str_mv | 10.1007/s12105-020-01135-1 |
| format | Article |
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MYC, BLC2
, and/or
BCL6
. These lymphomas are uncommon and aggressive, responding poorly to typical chemotherapy regimens. Lymphomas rarely arise from the oral cavity or tonsils, and those presenting as a neck mass are predominantly diffuse large B-cell lymphoma. To date, primary DHL of the tonsils has yet to be described in the literature. Here, we report a case of a 44 year-old male patient with well-controlled human immunodeficiency virus (HIV) who presented with a sore throat. He subsequently developed acute respiratory compromise due to a rapidly enlarging tonsillar mass. Pathologic and genetic analysis confirmed the presence of
BCL6
and
MYC
rearrangements suggestive of DHL of the tonsils. In a young patient with HIV and a neck mass, it is essential that lymphoma remains on the list of differential diagnoses as prompt diagnosis and treatment may prevent complications from its rapid expansion.</description><identifier>ISSN: 1936-0568</identifier><identifier>ISSN: 1936-055X</identifier><identifier>EISSN: 1936-0568</identifier><identifier>DOI: 10.1007/s12105-020-01135-1</identifier><identifier>PMID: 31997133</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Case Reports ; Dentistry ; Medicine ; Medicine & Public Health ; Oral and Maxillofacial Surgery ; Otorhinolaryngology ; Pathology</subject><ispartof>Head & neck pathology (Totowa, N.J.), 2020-12, Vol.14 (4), p.1129-1133</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-ed71982926bf590df9ecef914419df329d782ad069be5c875386f7836adc8d3e3</citedby><cites>FETCH-LOGICAL-c446t-ed71982926bf590df9ecef914419df329d782ad069be5c875386f7836adc8d3e3</cites><orcidid>0000-0002-3420-930X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669924/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669924/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31997133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hinkle, Chad</creatorcontrib><creatorcontrib>Makar, Gabriel S.</creatorcontrib><creatorcontrib>Brody, Joshua D.</creatorcontrib><creatorcontrib>Ahmad, Nadir</creatorcontrib><creatorcontrib>Zhu, Gord Guo</creatorcontrib><title>HIV-Associated “Double-Hit” Lymphoma of the Tonsil: A First Reported Case</title><title>Head & neck pathology (Totowa, N.J.)</title><addtitle>Head and Neck Pathol</addtitle><addtitle>Head Neck Pathol</addtitle><description>Double-hit lymphoma (DHL) is a unique subtype of non-Hodgkin lymphoma characterized by atleast two rearrangements involving
MYC, BLC2
, and/or
BCL6
. These lymphomas are uncommon and aggressive, responding poorly to typical chemotherapy regimens. Lymphomas rarely arise from the oral cavity or tonsils, and those presenting as a neck mass are predominantly diffuse large B-cell lymphoma. To date, primary DHL of the tonsils has yet to be described in the literature. Here, we report a case of a 44 year-old male patient with well-controlled human immunodeficiency virus (HIV) who presented with a sore throat. He subsequently developed acute respiratory compromise due to a rapidly enlarging tonsillar mass. Pathologic and genetic analysis confirmed the presence of
BCL6
and
MYC
rearrangements suggestive of DHL of the tonsils. In a young patient with HIV and a neck mass, it is essential that lymphoma remains on the list of differential diagnoses as prompt diagnosis and treatment may prevent complications from its rapid expansion.</description><subject>Case Reports</subject><subject>Dentistry</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Otorhinolaryngology</subject><subject>Pathology</subject><issn>1936-0568</issn><issn>1936-055X</issn><issn>1936-0568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UclKxEAQbURxGf0BD5Kjl9Zekl48CMO4jDAiiHptetIVJ5Kkx-5E8OaH6M_5JWYcFb14qoK3VPEeQruUHFBC5GGkjJIME0YwoZRnmK6gTaq5wCQTavXXvoG2YnwgRBCZknW0wanWknK-iS7HF3d4GKPPS9uCS95fXk98N60Aj8v2_eUtmTzX85mvbeKLpJ1BcuObWFZHyTA5K0Nsk2uY-7BQjmyEbbRW2CrCztccoNuz05vRGE-uzi9GwwnO01S0GJykWjHNxLTINHGFhhwKTdOUaldwpp1UzDoi9BSyXMmMK1FIxYV1uXIc-AAdL33n3bQGl0PTBluZeShrG56Nt6X5izTlzNz7JyOF0JqlvcH-l0Hwjx3E1tRlzKGqbAO-i4bxVEktM6p6KltS8-BjDFD8nKHELHowyx5M34P57MHQXrT3-8EfyXfwPYEvCbGHmnsI5sF3oelD-8_2A0TKlN4</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Hinkle, Chad</creator><creator>Makar, Gabriel S.</creator><creator>Brody, Joshua D.</creator><creator>Ahmad, Nadir</creator><creator>Zhu, Gord Guo</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3420-930X</orcidid></search><sort><creationdate>20201201</creationdate><title>HIV-Associated “Double-Hit” Lymphoma of the Tonsil: A First Reported Case</title><author>Hinkle, Chad ; Makar, Gabriel S. ; Brody, Joshua D. ; Ahmad, Nadir ; Zhu, Gord Guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-ed71982926bf590df9ecef914419df329d782ad069be5c875386f7836adc8d3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Case Reports</topic><topic>Dentistry</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Otorhinolaryngology</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hinkle, Chad</creatorcontrib><creatorcontrib>Makar, Gabriel S.</creatorcontrib><creatorcontrib>Brody, Joshua D.</creatorcontrib><creatorcontrib>Ahmad, Nadir</creatorcontrib><creatorcontrib>Zhu, Gord Guo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Head & neck pathology (Totowa, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hinkle, Chad</au><au>Makar, Gabriel S.</au><au>Brody, Joshua D.</au><au>Ahmad, Nadir</au><au>Zhu, Gord Guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-Associated “Double-Hit” Lymphoma of the Tonsil: A First Reported Case</atitle><jtitle>Head & neck pathology (Totowa, N.J.)</jtitle><stitle>Head and Neck Pathol</stitle><addtitle>Head Neck Pathol</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>14</volume><issue>4</issue><spage>1129</spage><epage>1133</epage><pages>1129-1133</pages><issn>1936-0568</issn><issn>1936-055X</issn><eissn>1936-0568</eissn><abstract>Double-hit lymphoma (DHL) is a unique subtype of non-Hodgkin lymphoma characterized by atleast two rearrangements involving
MYC, BLC2
, and/or
BCL6
. These lymphomas are uncommon and aggressive, responding poorly to typical chemotherapy regimens. Lymphomas rarely arise from the oral cavity or tonsils, and those presenting as a neck mass are predominantly diffuse large B-cell lymphoma. To date, primary DHL of the tonsils has yet to be described in the literature. Here, we report a case of a 44 year-old male patient with well-controlled human immunodeficiency virus (HIV) who presented with a sore throat. He subsequently developed acute respiratory compromise due to a rapidly enlarging tonsillar mass. Pathologic and genetic analysis confirmed the presence of
BCL6
and
MYC
rearrangements suggestive of DHL of the tonsils. In a young patient with HIV and a neck mass, it is essential that lymphoma remains on the list of differential diagnoses as prompt diagnosis and treatment may prevent complications from its rapid expansion.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31997133</pmid><doi>10.1007/s12105-020-01135-1</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3420-930X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Case Reports Dentistry Medicine Medicine & Public Health Oral and Maxillofacial Surgery Otorhinolaryngology Pathology |
| title | HIV-Associated “Double-Hit” Lymphoma of the Tonsil: A First Reported Case |
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