C17orf53 is identified as a novel gene involved in inter-strand crosslink repair

•C17orf53 promotes cell survival in response to ATR inhibition.•C17orf53-deficient cells show profound defect in response to ICL.•C17orf53 is a ssDNA-binding protein and directly interacts with RPA.•C17orf53 acts with MCM8/9 in DNA repair. Ataxia Telangiectasia and Rad3-Related kinase (ATR) is a mas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	DNA repair 2020-11, Vol.95, p.102946-102946, Article 102946
Hauptverfasser:	Wang, Chao, Chen, Zhen, Su, Dan, Tang, Mengfan, Nie, Litong, Zhang, Huimin, Feng, Xu, Wang, Rui, Shen, Xi, Srivastava, Mrinal, McLaughlin, Megan E., Hart, Traver, Li, Lei, Chen, Junjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence C17orf53 Cell Survival DNA Adducts - metabolism DNA Repair DNA Replication DNA, Single-Stranded - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Genome-wide screen Humans ICL repair Minichromosome Maintenance Proteins - metabolism Replication Protein A - metabolism RPA-binding, HROB, MCM8IP Sequence Alignment ssDNA-binding
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!