GBA variants in REM sleep behavior disorder: A multicenter study

OBJECTIVETo study the role of GBA variants in the risk for isolated REM sleep behavior disorder (iRBD) and conversion to overt neurodegeneration. METHODSA total of 4,147 individuals were included1,061 patients with iRBD and 3,086 controls. GBA was fully sequenced using molecular inversion probes and...

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Veröffentlicht in:	Neurology 2020-08, Vol.95 (8), p.e1008-e1016
Hauptverfasser:	Krohn, Lynne, Ruskey, Jennifer A., Rudakou, Uladzislau, Leveille, Etienne, Asayesh, Farnaz, Hu, Michele T.M., Arnulf, Isabelle, Dauvilliers, Yves, Högl, Birgit, Stefani, Ambra, Monaca, Christelle Charley, Abril, Beatriz, Plazzi, Giuseppe, Antelmi, Elena, Ferini-Strambi, Luigi, Heidbreder, Anna, Boeve, Bradley F., Espay, Alberto J., De Cock, Valérie Cochen, Mollenhauer, Brit, Sixel-Döring, Friederike, Trenkwalder, Claudia, Sonka, Karel, Kemlink, David, Figorilli, Michela, Puligheddu, Monica, Dijkstra, Femke, Viaene, Mineke, Oertel, Wolfgang, Toffoli, Marco, Gigli, Gian Luigi, Valente, Mariarosaria, Gagnon, Jean-François, Desautels, Alex, Montplaisir, Jacques Y., Postuma, Ronald B., Rouleau, Guy A., Gan-Or, Ziv
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Disease Progression Female Genetic Predisposition to Disease Genetic Predisposition to Disease - genetics Genetic Variation Glucosylceramidase Glucosylceramidase - genetics Humans Life Sciences Male Middle Aged Neurodegenerative Diseases Neurodegenerative Diseases - genetics Neurons and Cognition REM Sleep Behavior Disorder REM Sleep Behavior Disorder - genetics
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