FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition

Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor AZD1775 (WEE1i) over-rides cell cycle checkpoints and is being studied in HNSCC regimens. We show that the HPV16 E6/E7 oncoproteins s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-11, Vol.117 (45), p.28287-28296
Hauptverfasser:	Diab, Ahmed, Gem, Hakan, Swanger, Jherek, Kim, Hee Yeon, Smith, Kaleb, Zou, Grace, Raju, Sharat, Kao, Michael, Fitzgibbon, Matthew, Loeb, Keith R., Rodriguez, Cristina P., Méndez, Eduardo, Galloway, Denise A., Sidorova, Julia M., Clurman, Bruce E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cancer CDC2 Protein Kinase - metabolism Cell cycle Cell Cycle Checkpoints Cell Cycle Proteins - drug effects Cell Cycle Proteins - metabolism Cell Line, Tumor Circuits Deactivation Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Enzyme inhibitors Forkhead Box Protein M1 - metabolism Gene expression Genomes Genomic analysis Head & neck cancer Head and Neck Neoplasms Human papillomavirus Humans Inactivation Kinases Oncogene Proteins, Viral - metabolism p53 Protein Papillomavirus E7 Proteins - metabolism Papillomavirus Infections - drug therapy Phenotypes Protein-Tyrosine Kinases - drug effects Protein-Tyrosine Kinases - metabolism Pyrazoles - antagonists & inhibitors Pyrimidinones - antagonists & inhibitors Repressor Proteins - metabolism Sensitivity Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Toxicity Transcription Tumors Up-Regulation Viruses
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