Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell

Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive-age women associated with mutations in tuberous sclerosis complex genes. LAM causes cystic remodeling of the lung and progressive respiratory failure. The sources and cellular characteristics of LAM cells underlying disease path...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2020-11, Vol.202 (10), p.1373-1387
Hauptverfasser:	Guo, Minzhe, Yu, Jane J, Perl, Anne Karina, Wikenheiser-Brokamp, Kathryn A, Riccetti, Matt, Zhang, Erik Y, Sudha, Parvathi, Adam, Mike, Potter, Andrew, Kopras, Elizabeth J, Giannikou, Krinio, Potter, S Steven, Sherman, Sue, Hammes, Stephen R, Kwiatkowski, David J, Whitsett, Jeffrey A, McCormack, Francis X, Xu, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers Biomarkers, Tumor - genetics Cells Cellular biology Female Humans Lung diseases Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lymphangioleiomyomatosis - diagnosis Lymphangioleiomyomatosis - genetics Medical research Middle Aged Original Pathogenesis Single-Cell Analysis Systemic diseases Transcriptome - genetics United States Uterine Neoplasms - diagnosis Uterine Neoplasms - genetics
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