Chemical Modification of Linkers Provides Stable Linker–Payloads for the Generation of Antibody–Drug Conjugates

Stability of antibody–drug conjugates (ADCs) in mouse serum is one of the critical requirements for the evaluation of ADCs in mouse tumor models. Described herein is a strategy to address the mouse serum instability of uncialamycin linker–payloads through various chemical approaches that involve mod...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS medicinal chemistry letters 2020-11, Vol.11 (11), p.2190-2194
Hauptverfasser:	Poudel, Yam B, Chowdari, Naidu S, Cheng, Heng, Iwuagwu, Christiana I, King, H. Dalton, Kotapati, Srikanth, Passmore, David, Rampulla, Richard, Mathur, Arvind, Vite, Gregory, Gangwar, Sanjeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!