High‐Throughput Tumor‐on‐a‐Chip Platform to Study Tumor–Stroma Interactions and Drug Pharmacokinetics

Drug screening in oncology, especially for triple‐negative breast cancer (TNBC), has high demand but remains unsatisfactory. Currently available models are either nonrepresentative of the complex tumor microenvironment or only suitable for low throughput screening, resulting in a low‐yield success f...

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Veröffentlicht in:	Advanced healthcare materials 2020-11, Vol.9 (21), p.e2000880-n/a
Hauptverfasser:	Chi, Chun‐Wei, Lao, Yeh‐Hsing, Ahmed, A. H. Rezwanuddin, Benoy, Elizabeth C., Li, Chenghai, Dereli‐Korkut, Zeynep, Fu, Bingmei M., Leong, Kam W., Wang, Sihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Breast cancer Cancer Cancer-Associated Fibroblasts Caspase Cell Line, Tumor Doxorubicin Drug development Drug screening Endothelium Fibroblasts High-throughput screening Humans Lab-On-A-Chip Devices Mesenchyme Microfluidics Microvasculature Modular design Oncology Pharmaceutical Preparations Pharmacokinetics Pharmacology Screening Stem cells Stromal cells Toolkits Tumor Microenvironment tumor microenvironments Tumors tumor‐on‐a‐chip
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