Study of the Mechanism Underlying the Antihypertensive Effects of Eucommia ulmoides and Tribulus terrestris Based on an Analysis of the Intestinal Microbiota and Metabonomics

The combination of Eucommia ulmoides and Tribulus terrestris (ET) has been widely utilized in clinical practice for thousands of years, but the mechanism underlying its efficacy has not been elucidated to date. This study attempted to investigate the role played by the intestinal microbiota and feca...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-12
Hauptverfasser:	Jiang, Ling-Yu, Shao, Lin-Lin, Jiang, Yue-Hua, Yang, Xue-Song, Qi, Ying-Zi, Yang, Chuan-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Algorithms Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Antihypertensive drugs Antihypertensives Biomarkers Biomarkers, Pharmacological - analysis Blood pressure Blood Pressure - drug effects Chemical properties Chenodeoxycholic acid Chinese medicine Chromatography Colon - drug effects Correlation analysis Data processing Deoxycholic acid Deoxyribonucleic acid DNA Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Eucommia ulmoides Eucommiaceae - chemistry Feces Feces - microbiology Gas chromatography Gas Chromatography-Mass Spectrometry Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Health aspects Hypertension Intestinal microflora Intestine Laboratory animals Male Mass spectrometry Mass spectroscopy Medicine, Chinese Metabolism Metabolites Metabolomics - methods Microbiota Microbiota (Symbiotic organisms) Morphology Pharmacology, Experimental Phenylalanine Plant Extracts - chemistry Plant Extracts - pharmacology Plant metabolites Protein turnover Rats, Inbred SHR Rats, Inbred WKY RNA, Ribosomal, 16S rRNA 16S Scientific imaging Software Tocopherol Tribulus Tribulus - chemistry Tribulus terrestris Variance analysis Vitamin E
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