A Novel PET Probe for Brown Adipose Tissue Imaging in Rodents

Purpose Brown adipose tissue (BAT) has emerged as a promising target to counteract obesity and its associated metabolic disorders. However, the detection of this tissue remains one of the major roadblocks. Procedures In this study, we assess the use of BODIPY 1 as a positron emission tomography (PET...

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Veröffentlicht in:	Molecular imaging and biology 2020-06, Vol.22 (3), p.675-684
Hauptverfasser:	Wang, Hui, Wang, Mengzhe, Chansaenpak, Kantapat, Liu, Yang, Yuan, Hong, Xie, Jin, Yin, Hang, Branca, Rosa T., Li, Zibo, Wu, Zhanhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adipocytes Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - diagnostic imaging Adipose Tissue, Brown - metabolism Animal tissues Animals Boron Compounds - chemistry Boron Compounds - pharmacokinetics Cell Line, Tumor Emission analysis Evaluation Fluorescence Fluorescence microscopy Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacokinetics Fluorine isotopes Fluorine Radioisotopes - chemistry Fluorodeoxyglucose F18 - chemistry Fluorodeoxyglucose F18 - pharmacokinetics Genotypes Glucose Imaging Male Medical imaging Medicine Medicine & Public Health Metabolic disorders Mice Mice, Inbred BALB C Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Norepinephrine Obesity Phenotypes Positron emission Positron emission tomography Positron-Emission Tomography - methods Radioactivity Radiology Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Research Article Rodents Signal processing Thermogenesis Tomography
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