Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias

Mutations in KCNH2 can lead to long QT syndrome type 2. Variable disease manifestation observed with this channelopathy is associated with the location and type of mutation within the protein, complicating efforts to predict patient risk. Here, we demonstrated phenotypic differences in cardiomyocyte...

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Veröffentlicht in:	Stem cell reports 2020-11, Vol.15 (5), p.1127-1139
Hauptverfasser:	Brandão, Karina O., van den Brink, Lettine, Miller, Duncan C., Grandela, Catarina, van Meer, Berend J., Mol, Mervyn P.H., de Korte, Tessa, Tertoolen, Leon G.J., Mummery, Christine L., Sala, Luca, Verkerk, Arie O., Davis, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	arrhythmia disease modeling electrophysiology genome editing induced pluripotent stem cells isogenic long QT syndrome 2 risk stratification
Online-Zugang:	Volltext
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