NAA10 as a New Prognostic Marker for Cancer Progression
N-α-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins. NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the over...
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| Veröffentlicht in: | International journal of molecular sciences 2020-10, Vol.21 (21), p.8010 |
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| creator | Kim, Sun Myung Ha, Eunyoung Kim, Jinyoung Cho, Chiheum Shin, So-Jin Seo, Ji Hae |
| description | N-α-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins. NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the overexpression of NAA10 in various types of cancer, including liver, bone, lung, breast, colon, and prostate cancers, and demonstrated a correlation of overexpressed NAA10 with vascular invasion and metastasis, thereby affecting overall survival rates of cancer patients and recurrence of diseases. This evidence all points NAA10 toward a promising biomarker for cancer prognosis. Here we summarize the current knowledge regarding the biological functions of NAA10 in cancer progression and provide the potential usage of NAA10 as a prognostic marker for cancer progression. |
| doi_str_mv | 10.3390/ijms21218010 |
| format | Article |
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NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the overexpression of NAA10 in various types of cancer, including liver, bone, lung, breast, colon, and prostate cancers, and demonstrated a correlation of overexpressed NAA10 with vascular invasion and metastasis, thereby affecting overall survival rates of cancer patients and recurrence of diseases. This evidence all points NAA10 toward a promising biomarker for cancer prognosis. Here we summarize the current knowledge regarding the biological functions of NAA10 in cancer progression and provide the potential usage of NAA10 as a prognostic marker for cancer progression.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21218010</identifier><identifier>PMID: 33126484</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetyltransferase ; Amino acids ; Androgens ; Apoptosis ; Autophagy ; Binding sites ; Biomarkers ; Biomarkers, Tumor - metabolism ; Bone cancer ; Breast ; Cancer ; Cell cycle ; Cell differentiation ; Cell proliferation ; Colon ; Disease Progression ; Gene expression ; Humans ; Kinases ; Liver cancer ; Localization ; Lung cancer ; Lysine ; Metastases ; N-Terminal Acetyltransferase A - metabolism ; N-Terminal Acetyltransferase E - metabolism ; Neoplasms - metabolism ; Neoplasms - pathology ; Phagocytosis ; Phosphorylation ; Physiology ; Prostate ; Prostate cancer ; Proteins ; Review ; Roles ; Tumorigenesis</subject><ispartof>International journal of molecular sciences, 2020-10, Vol.21 (21), p.8010</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the overexpression of NAA10 in various types of cancer, including liver, bone, lung, breast, colon, and prostate cancers, and demonstrated a correlation of overexpressed NAA10 with vascular invasion and metastasis, thereby affecting overall survival rates of cancer patients and recurrence of diseases. This evidence all points NAA10 toward a promising biomarker for cancer prognosis. Here we summarize the current knowledge regarding the biological functions of NAA10 in cancer progression and provide the potential usage of NAA10 as a prognostic marker for cancer progression.</description><subject>Acetyltransferase</subject><subject>Amino acids</subject><subject>Androgens</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Binding sites</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Bone cancer</subject><subject>Breast</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Colon</subject><subject>Disease Progression</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Localization</subject><subject>Lung cancer</subject><subject>Lysine</subject><subject>Metastases</subject><subject>N-Terminal Acetyltransferase A - metabolism</subject><subject>N-Terminal Acetyltransferase E - metabolism</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Phagocytosis</subject><subject>Phosphorylation</subject><subject>Physiology</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Review</subject><subject>Roles</subject><subject>Tumorigenesis</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1Lw0AUxBdRrFZvniXgxYPR_XjZJBehFL-gVg96XnY3uzU1ydbdRPG_N6W1VE9vYH4MbxiETgi-ZCzHV-W8DpRQkmGCd9ABAUpjjHm6u6UH6DCEOcaU0STfRwPGCOWQwQFKp6MRwZEMkYym5it69m7WuNCWOnqU_t34yDofjWWje7k0vQmhdM0R2rOyCuZ4fYfo9fbmZXwfT57uHsajSayB0DZOJS04JGCYIpnVoIpCMi4lZzaXBc8AQBMmNdACcottnrIEiFJYKc4VUWyIrle5i07VptCmab2sxMKXtfTfwslS_HWa8k3M3KdIOWeE0T7gfB3g3UdnQivqMmhTVbIxrguCQsKBYE55j579Q-eu801fT9AEMp7gnC2pixWlvQvBG7t5hmCxXERsL9Ljp9sFNvDvBOwHzUOFjA</recordid><startdate>20201028</startdate><enddate>20201028</enddate><creator>Kim, Sun Myung</creator><creator>Ha, Eunyoung</creator><creator>Kim, Jinyoung</creator><creator>Cho, Chiheum</creator><creator>Shin, So-Jin</creator><creator>Seo, Ji Hae</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9597-9834</orcidid></search><sort><creationdate>20201028</creationdate><title>NAA10 as a New Prognostic Marker for Cancer Progression</title><author>Kim, Sun Myung ; Ha, Eunyoung ; Kim, Jinyoung ; Cho, Chiheum ; Shin, So-Jin ; Seo, Ji Hae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-7a2d6454e3b18fc4bdda36aa63f9ad68444c13ac42d49f0f973541bb0bb66b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetyltransferase</topic><topic>Amino acids</topic><topic>Androgens</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Binding sites</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Bone cancer</topic><topic>Breast</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Colon</topic><topic>Disease Progression</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Localization</topic><topic>Lung cancer</topic><topic>Lysine</topic><topic>Metastases</topic><topic>N-Terminal Acetyltransferase A - metabolism</topic><topic>N-Terminal Acetyltransferase E - metabolism</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Phagocytosis</topic><topic>Phosphorylation</topic><topic>Physiology</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Proteins</topic><topic>Review</topic><topic>Roles</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sun Myung</creatorcontrib><creatorcontrib>Ha, Eunyoung</creatorcontrib><creatorcontrib>Kim, Jinyoung</creatorcontrib><creatorcontrib>Cho, Chiheum</creatorcontrib><creatorcontrib>Shin, So-Jin</creatorcontrib><creatorcontrib>Seo, Ji Hae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sun Myung</au><au>Ha, Eunyoung</au><au>Kim, Jinyoung</au><au>Cho, Chiheum</au><au>Shin, So-Jin</au><au>Seo, Ji Hae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NAA10 as a New Prognostic Marker for Cancer Progression</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-10-28</date><risdate>2020</risdate><volume>21</volume><issue>21</issue><spage>8010</spage><pages>8010-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>N-α-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins. NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the overexpression of NAA10 in various types of cancer, including liver, bone, lung, breast, colon, and prostate cancers, and demonstrated a correlation of overexpressed NAA10 with vascular invasion and metastasis, thereby affecting overall survival rates of cancer patients and recurrence of diseases. This evidence all points NAA10 toward a promising biomarker for cancer prognosis. Here we summarize the current knowledge regarding the biological functions of NAA10 in cancer progression and provide the potential usage of NAA10 as a prognostic marker for cancer progression.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33126484</pmid><doi>10.3390/ijms21218010</doi><orcidid>https://orcid.org/0000-0002-9597-9834</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetyltransferase Amino acids Androgens Apoptosis Autophagy Binding sites Biomarkers Biomarkers, Tumor - metabolism Bone cancer Breast Cancer Cell cycle Cell differentiation Cell proliferation Colon Disease Progression Gene expression Humans Kinases Liver cancer Localization Lung cancer Lysine Metastases N-Terminal Acetyltransferase A - metabolism N-Terminal Acetyltransferase E - metabolism Neoplasms - metabolism Neoplasms - pathology Phagocytosis Phosphorylation Physiology Prostate Prostate cancer Proteins Review Roles Tumorigenesis |
| title | NAA10 as a New Prognostic Marker for Cancer Progression |
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