Adaptation by copy number variation increases insecticide resistance in the fall armyworm
Understanding the genetic basis of insecticide resistance is a key topic in agricultural ecology. The adaptive evolution of multi-copy detoxification genes has been interpreted as a cause of insecticide resistance, yet the same pattern can also be generated by the adaptation to host-plant defense to...
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| Veröffentlicht in: | Communications biology 2020-11, Vol.3 (1), p.664-664, Article 664 |
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| creator | Gimenez, Sylvie Abdelgaffar, Heba Goff, Gaelle Le Hilliou, Frédérique Blanco, Carlos A. Hänniger, Sabine Bretaudeau, Anthony Legeai, Fabrice Nègre, Nicolas Jurat-Fuentes, Juan Luis d’Alençon, Emmanuelle Nam, Kiwoong |
| description | Understanding the genetic basis of insecticide resistance is a key topic in agricultural ecology. The adaptive evolution of multi-copy detoxification genes has been interpreted as a cause of insecticide resistance, yet the same pattern can also be generated by the adaptation to host-plant defense toxins. In this study, we tested in the fall armyworm,
Spodoptera frugiperda
(Lepidoptera: Noctuidae), if adaptation by copy number variation caused insecticide resistance in two geographically distinct populations with different levels of resistance and the two host-plant strains. We observed a significant allelic differentiation of genomic copy number variations between the two geographic populations, but not between host-plant strains. A locus with positively selected copy number variation included a CYP gene cluster. Toxicological tests supported a central role for CYP enzymes in deltamethrin resistance. Our results indicate that copy number variation of detoxification genes might be responsible for insecticide resistance in fall armyworm and that evolutionary forces causing insecticide resistance could be independent of host-plant adaptation.
Sylvie Gimenez et al. compare adaptation by copy number variation in two geographically distinct populations of the fall armyworm and find a relationship between copy number variation and insecticide resistance. The authors perform toxicological tests to confirm a role of the CYP gene cluster in insecticide resistance and suggest that evolutionary forces causing insecticide resistance can be independent of host-plant adaptation. |
| doi_str_mv | 10.1038/s42003-020-01382-6 |
| format | Article |
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Spodoptera frugiperda
(Lepidoptera: Noctuidae), if adaptation by copy number variation caused insecticide resistance in two geographically distinct populations with different levels of resistance and the two host-plant strains. We observed a significant allelic differentiation of genomic copy number variations between the two geographic populations, but not between host-plant strains. A locus with positively selected copy number variation included a CYP gene cluster. Toxicological tests supported a central role for CYP enzymes in deltamethrin resistance. Our results indicate that copy number variation of detoxification genes might be responsible for insecticide resistance in fall armyworm and that evolutionary forces causing insecticide resistance could be independent of host-plant adaptation.
Sylvie Gimenez et al. compare adaptation by copy number variation in two geographically distinct populations of the fall armyworm and find a relationship between copy number variation and insecticide resistance. The authors perform toxicological tests to confirm a role of the CYP gene cluster in insecticide resistance and suggest that evolutionary forces causing insecticide resistance can be independent of host-plant adaptation.</description><identifier>ISSN: 2399-3642</identifier><identifier>EISSN: 2399-3642</identifier><identifier>DOI: 10.1038/s42003-020-01382-6</identifier><identifier>PMID: 33184418</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/22 ; 45/23 ; 631/181/2474 ; 631/181/457/649/2157 ; Adaptation ; Animals ; Bioinformatics ; Biology ; Biomedical and Life Sciences ; Computer Science ; Copy number ; CYP gene ; Cytochrome P-450 Enzyme System - genetics ; Deltamethrin ; Detoxification ; DNA Copy Number Variations - genetics ; Evolution & development ; Evolutionary genetics ; Female ; Genes ; Genome, Insect - genetics ; Host plants ; Insecticide Resistance - genetics ; Insecticides ; Insecticides - pharmacology ; Life Sciences ; Nitriles - pharmacology ; Pesticide resistance ; Pyrethrins - pharmacology ; Spodoptera - drug effects ; Spodoptera - genetics ; Spodoptera frugiperda</subject><ispartof>Communications biology, 2020-11, Vol.3 (1), p.664-664, Article 664</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-17530dcebe2e74bf975a9df647236cc48f8f9e28deb6b5635a38ec685600e2ee3</citedby><cites>FETCH-LOGICAL-c508t-17530dcebe2e74bf975a9df647236cc48f8f9e28deb6b5635a38ec685600e2ee3</cites><orcidid>0000-0001-8758-3568 ; 0000-0001-8994-0119 ; 0000-0003-2547-8302 ; 0000-0003-0914-2470 ; 0000-0001-9727-3416 ; 0000-0003-3194-8673 ; 0000-0002-6472-4839 ; 0000-0002-8945-1814 ; 0000-0001-6187-3057 ; 0000-0002-3020-2987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661717/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661717/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33184418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inria.hal.science/hal-03065279$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Gimenez, Sylvie</creatorcontrib><creatorcontrib>Abdelgaffar, Heba</creatorcontrib><creatorcontrib>Goff, Gaelle Le</creatorcontrib><creatorcontrib>Hilliou, Frédérique</creatorcontrib><creatorcontrib>Blanco, Carlos A.</creatorcontrib><creatorcontrib>Hänniger, Sabine</creatorcontrib><creatorcontrib>Bretaudeau, Anthony</creatorcontrib><creatorcontrib>Legeai, Fabrice</creatorcontrib><creatorcontrib>Nègre, Nicolas</creatorcontrib><creatorcontrib>Jurat-Fuentes, Juan Luis</creatorcontrib><creatorcontrib>d’Alençon, Emmanuelle</creatorcontrib><creatorcontrib>Nam, Kiwoong</creatorcontrib><title>Adaptation by copy number variation increases insecticide resistance in the fall armyworm</title><title>Communications biology</title><addtitle>Commun Biol</addtitle><addtitle>Commun Biol</addtitle><description>Understanding the genetic basis of insecticide resistance is a key topic in agricultural ecology. The adaptive evolution of multi-copy detoxification genes has been interpreted as a cause of insecticide resistance, yet the same pattern can also be generated by the adaptation to host-plant defense toxins. In this study, we tested in the fall armyworm,
Spodoptera frugiperda
(Lepidoptera: Noctuidae), if adaptation by copy number variation caused insecticide resistance in two geographically distinct populations with different levels of resistance and the two host-plant strains. We observed a significant allelic differentiation of genomic copy number variations between the two geographic populations, but not between host-plant strains. A locus with positively selected copy number variation included a CYP gene cluster. Toxicological tests supported a central role for CYP enzymes in deltamethrin resistance. Our results indicate that copy number variation of detoxification genes might be responsible for insecticide resistance in fall armyworm and that evolutionary forces causing insecticide resistance could be independent of host-plant adaptation.
Sylvie Gimenez et al. compare adaptation by copy number variation in two geographically distinct populations of the fall armyworm and find a relationship between copy number variation and insecticide resistance. The authors perform toxicological tests to confirm a role of the CYP gene cluster in insecticide resistance and suggest that evolutionary forces causing insecticide resistance can be independent of host-plant adaptation.</description><subject>45</subject><subject>45/22</subject><subject>45/23</subject><subject>631/181/2474</subject><subject>631/181/457/649/2157</subject><subject>Adaptation</subject><subject>Animals</subject><subject>Bioinformatics</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Computer Science</subject><subject>Copy number</subject><subject>CYP gene</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Deltamethrin</subject><subject>Detoxification</subject><subject>DNA Copy Number Variations - genetics</subject><subject>Evolution & development</subject><subject>Evolutionary genetics</subject><subject>Female</subject><subject>Genes</subject><subject>Genome, Insect - genetics</subject><subject>Host plants</subject><subject>Insecticide Resistance - 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genetics</topic><topic>Deltamethrin</topic><topic>Detoxification</topic><topic>DNA Copy Number Variations - genetics</topic><topic>Evolution & development</topic><topic>Evolutionary genetics</topic><topic>Female</topic><topic>Genes</topic><topic>Genome, Insect - genetics</topic><topic>Host plants</topic><topic>Insecticide Resistance - genetics</topic><topic>Insecticides</topic><topic>Insecticides - pharmacology</topic><topic>Life Sciences</topic><topic>Nitriles - pharmacology</topic><topic>Pesticide resistance</topic><topic>Pyrethrins - pharmacology</topic><topic>Spodoptera - drug effects</topic><topic>Spodoptera - genetics</topic><topic>Spodoptera frugiperda</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gimenez, Sylvie</creatorcontrib><creatorcontrib>Abdelgaffar, Heba</creatorcontrib><creatorcontrib>Goff, Gaelle Le</creatorcontrib><creatorcontrib>Hilliou, Frédérique</creatorcontrib><creatorcontrib>Blanco, Carlos A.</creatorcontrib><creatorcontrib>Hänniger, Sabine</creatorcontrib><creatorcontrib>Bretaudeau, Anthony</creatorcontrib><creatorcontrib>Legeai, Fabrice</creatorcontrib><creatorcontrib>Nègre, Nicolas</creatorcontrib><creatorcontrib>Jurat-Fuentes, Juan Luis</creatorcontrib><creatorcontrib>d’Alençon, Emmanuelle</creatorcontrib><creatorcontrib>Nam, Kiwoong</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Communications biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gimenez, Sylvie</au><au>Abdelgaffar, Heba</au><au>Goff, Gaelle Le</au><au>Hilliou, Frédérique</au><au>Blanco, Carlos A.</au><au>Hänniger, Sabine</au><au>Bretaudeau, Anthony</au><au>Legeai, Fabrice</au><au>Nègre, Nicolas</au><au>Jurat-Fuentes, Juan Luis</au><au>d’Alençon, Emmanuelle</au><au>Nam, Kiwoong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adaptation by copy number variation increases insecticide resistance in the fall armyworm</atitle><jtitle>Communications biology</jtitle><stitle>Commun Biol</stitle><addtitle>Commun Biol</addtitle><date>2020-11-12</date><risdate>2020</risdate><volume>3</volume><issue>1</issue><spage>664</spage><epage>664</epage><pages>664-664</pages><artnum>664</artnum><issn>2399-3642</issn><eissn>2399-3642</eissn><abstract>Understanding the genetic basis of insecticide resistance is a key topic in agricultural ecology. The adaptive evolution of multi-copy detoxification genes has been interpreted as a cause of insecticide resistance, yet the same pattern can also be generated by the adaptation to host-plant defense toxins. In this study, we tested in the fall armyworm,
Spodoptera frugiperda
(Lepidoptera: Noctuidae), if adaptation by copy number variation caused insecticide resistance in two geographically distinct populations with different levels of resistance and the two host-plant strains. We observed a significant allelic differentiation of genomic copy number variations between the two geographic populations, but not between host-plant strains. A locus with positively selected copy number variation included a CYP gene cluster. Toxicological tests supported a central role for CYP enzymes in deltamethrin resistance. Our results indicate that copy number variation of detoxification genes might be responsible for insecticide resistance in fall armyworm and that evolutionary forces causing insecticide resistance could be independent of host-plant adaptation.
Sylvie Gimenez et al. compare adaptation by copy number variation in two geographically distinct populations of the fall armyworm and find a relationship between copy number variation and insecticide resistance. The authors perform toxicological tests to confirm a role of the CYP gene cluster in insecticide resistance and suggest that evolutionary forces causing insecticide resistance can be independent of host-plant adaptation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33184418</pmid><doi>10.1038/s42003-020-01382-6</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8758-3568</orcidid><orcidid>https://orcid.org/0000-0001-8994-0119</orcidid><orcidid>https://orcid.org/0000-0003-2547-8302</orcidid><orcidid>https://orcid.org/0000-0003-0914-2470</orcidid><orcidid>https://orcid.org/0000-0001-9727-3416</orcidid><orcidid>https://orcid.org/0000-0003-3194-8673</orcidid><orcidid>https://orcid.org/0000-0002-6472-4839</orcidid><orcidid>https://orcid.org/0000-0002-8945-1814</orcidid><orcidid>https://orcid.org/0000-0001-6187-3057</orcidid><orcidid>https://orcid.org/0000-0002-3020-2987</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 45 45/22 45/23 631/181/2474 631/181/457/649/2157 Adaptation Animals Bioinformatics Biology Biomedical and Life Sciences Computer Science Copy number CYP gene Cytochrome P-450 Enzyme System - genetics Deltamethrin Detoxification DNA Copy Number Variations - genetics Evolution & development Evolutionary genetics Female Genes Genome, Insect - genetics Host plants Insecticide Resistance - genetics Insecticides Insecticides - pharmacology Life Sciences Nitriles - pharmacology Pesticide resistance Pyrethrins - pharmacology Spodoptera - drug effects Spodoptera - genetics Spodoptera frugiperda |
| title | Adaptation by copy number variation increases insecticide resistance in the fall armyworm |
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