Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin‐dependent kinases and the phosphoinositide 3‐kinase/AKT signaling cascade

Increasing evidence suggests that PRMT5, a protein arginine methyltransferase, is involved in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming activity of PRMT5. We investigated the involvement of PRMT5 in tumor formation. First, we showed that PRMT5 was associat...

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Veröffentlicht in:	Cancer science 2012-09, Vol.103 (9), p.1640-1650
Hauptverfasser:	Wei, Tong‐You W., Juan, Chi‐Chang, Hisa, Jiun‐Yi, Su, Li‐Jen, Lee, Yuan‐Chii G., Chou, Hsiang‐Yun, Chen, Jo‐Mei M., Wu, Yu‐Chung, Chiu, Shao‐Chih, Hsu, Chung‐Ping, Liu, Kuo‐Lin, Yu, Chang‐Tze R.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals c-Jun amino-terminal kinase c-Jun protein Cell adhesion Cell cycle Cell density Cell Line, Tumor Cell proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism cyclin D1 Cyclin-dependent kinase Cyclin-Dependent Kinases - metabolism Cyclins Data processing G1 Phase Gene Expression Regulation, Neoplastic Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Mice Mice, Nude Oncogene Proteins - genetics Oncogene Proteins - metabolism Original Phosphatidylinositol 3-Kinases - metabolism phosphoinositides protein arginine methyltransferase Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Proto-Oncogene Proteins c-akt - metabolism Retinoblastoma protein Signal Transduction Statistical analysis Transcription factors Tumor cell lines Tumorigenesis Western blotting
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