SYT‐SSX breakpoint peptide vaccines in patients with synovial sarcoma: A study from the Japanese Musculoskeletal Oncology Group

In the present study, we evaluated the safety and effectiveness of SYT‐SSX‐derived peptide vaccines in patients with advanced synovial sarcoma. A 9‐mer peptide spanning the SYT‐SSX fusion region (B peptide) and its HLA‐A*2402 anchor substitute (K9I) were synthesized. In Protocols A1 and A2, vaccines...

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Veröffentlicht in:	Cancer science 2012-09, Vol.103 (9), p.1625-1630
Hauptverfasser:	Kawaguchi, Satoshi, Tsukahara, Tomohide, Ida, Kazunori, Kimura, Shigeharu, Murase, Masaki, Kano, Masanobu, Emori, Makoto, Nagoya, Satoshi, Kaya, Mitsunori, Torigoe, Toshihiko, Ueda, Emiri, Takahashi, Akari, Ishii, Takeshi, Tatezaki, Shin‐ichiro, Toguchida, Junya, Tsuchiya, Hiroyuki, Osanai, Toshihisa, Sugita, Takashi, Sugiura, Hideshi, Ieguchi, Makoto, Ihara, Koichiro, Hamada, Ken‐ichiro, Kakizaki, Hiroshi, Morii, Takeshi, Yasuda, Taketoshi, Tanizawa, Taisuke, Ogose, Akira, Yabe, Hiroo, Yamashita, Toshihiko, Sato, Noriyuki, Wada, Takuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cancer Vaccines - administration & dosage Cancer Vaccines - adverse effects Cancer Vaccines - therapeutic use Female HLA-A Antigens - immunology Humans Lung Neoplasms - immunology Lung Neoplasms - secondary Lung Neoplasms - therapy Male Middle Aged Oncogene Proteins, Fusion - immunology Original Sarcoma, Synovial - drug therapy Sarcoma, Synovial - immunology Sarcoma, Synovial - pathology T-Lymphocytes, Cytotoxic - immunology Treatment Outcome Vaccines, Subunit - administration & dosage Vaccines, Subunit - adverse effects Vaccines, Subunit - therapeutic use Young Adult
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