Prediagnostic smoking and postoperative survival in lymph node‐negative esophagus squamous cell carcinoma patients
Smoking is well known as a risk factor for esophageal cancer, but controversial as a prognostic factor. Moreover, evidence is scarce that a dose–response relationship exists. We conducted a retrospective study on the effect and dose–response relationship of prediagnostic smoking on the postoperative...
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| Veröffentlicht in: | Cancer science 2012-11, Vol.103 (11), p.1985-1988 |
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| container_end_page | 1988 |
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| container_issue | 11 |
| container_start_page | 1985 |
| container_title | Cancer science |
| container_volume | 103 |
| creator | Lin, Yongbin Su, Xiaodong Su, Hongyu Lin, Peng Long, Hao Zhang, Lanjun Fu, Jianhua Rong, Tiehua Tan, Zihui Meng, Yuqi Ma, Guowei |
| description | Smoking is well known as a risk factor for esophageal cancer, but controversial as a prognostic factor. Moreover, evidence is scarce that a dose–response relationship exists. We conducted a retrospective study on the effect and dose–response relationship of prediagnostic smoking on the postoperative disease‐specific survival of patients with lymph node‐negative esophageal squamous cell carcinoma (ESCC). We enrolled 643 patients with lymph node‐negative ESCC who had undergone esophagectomy between 1990 and 2005 at the Department of Thoracic Surgery, Sun Yat‐sen University Cancer Center, Guangzhou, China. The patients' demographic, pathological, preoperative and cancer outcome data were obtained from medical records. These data were reviewed and analyzed using life table, Kaplan–Meier analysis and multivariate Cox regression. A significant reduction in 3‐ and 5‐year survival rates was observed in smokers with lymph node‐negative ESCC compared with those in non‐smokers. The 3‐ and 5‐year survival rates were 54% and 46% for smokers, and 67% and 64% for non‐drinkers, respectively (P |
| doi_str_mv | 10.1111/cas.12000 |
| format | Article |
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Moreover, evidence is scarce that a dose–response relationship exists. We conducted a retrospective study on the effect and dose–response relationship of prediagnostic smoking on the postoperative disease‐specific survival of patients with lymph node‐negative esophageal squamous cell carcinoma (ESCC). We enrolled 643 patients with lymph node‐negative ESCC who had undergone esophagectomy between 1990 and 2005 at the Department of Thoracic Surgery, Sun Yat‐sen University Cancer Center, Guangzhou, China. The patients' demographic, pathological, preoperative and cancer outcome data were obtained from medical records. These data were reviewed and analyzed using life table, Kaplan–Meier analysis and multivariate Cox regression. A significant reduction in 3‐ and 5‐year survival rates was observed in smokers with lymph node‐negative ESCC compared with those in non‐smokers. The 3‐ and 5‐year survival rates were 54% and 46% for smokers, and 67% and 64% for non‐drinkers, respectively (P < 0.05). Multivariate Cox analysis revealed that smoking was an independent prognostic factor (P = 0.008, hazard ratio = 1.404). Both log‐rank test (P = 0.065) and multivariate analysis (P = 0.091) showed no significant difference between the survival rates of light and heavy smokers. Prediagnostic smoking is an independent prognostic factor for patients with lymph node‐negative ESCC, but the dose–response relationship needs further investigation.</description><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/cas.12000</identifier><identifier>PMID: 22913634</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adult ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; China ; Dose-Response Relationship, Drug ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagectomy - methods ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis - pathology ; Male ; Middle Aged ; Multivariate Analysis ; Original ; Postoperative Period ; Prognosis ; Retrospective Studies ; Smoking - adverse effects ; Smoking - epidemiology ; Survival Rate</subject><ispartof>Cancer science, 2012-11, Vol.103 (11), p.1985-1988</ispartof><rights>2012 Japanese Cancer Association</rights><rights>2012 Japanese Cancer Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4390-87ed42ebfb36dc4c402d4d662eedd7c0fe53edb98a84f371558b9608c144d1bf3</citedby><cites>FETCH-LOGICAL-c4390-87ed42ebfb36dc4c402d4d662eedd7c0fe53edb98a84f371558b9608c144d1bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659197/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659197/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcas.12000$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22913634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yongbin</creatorcontrib><creatorcontrib>Su, Xiaodong</creatorcontrib><creatorcontrib>Su, Hongyu</creatorcontrib><creatorcontrib>Lin, Peng</creatorcontrib><creatorcontrib>Long, Hao</creatorcontrib><creatorcontrib>Zhang, Lanjun</creatorcontrib><creatorcontrib>Fu, Jianhua</creatorcontrib><creatorcontrib>Rong, Tiehua</creatorcontrib><creatorcontrib>Tan, Zihui</creatorcontrib><creatorcontrib>Meng, Yuqi</creatorcontrib><creatorcontrib>Ma, Guowei</creatorcontrib><title>Prediagnostic smoking and postoperative survival in lymph node‐negative esophagus squamous cell carcinoma patients</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Smoking is well known as a risk factor for esophageal cancer, but controversial as a prognostic factor. Moreover, evidence is scarce that a dose–response relationship exists. We conducted a retrospective study on the effect and dose–response relationship of prediagnostic smoking on the postoperative disease‐specific survival of patients with lymph node‐negative esophageal squamous cell carcinoma (ESCC). We enrolled 643 patients with lymph node‐negative ESCC who had undergone esophagectomy between 1990 and 2005 at the Department of Thoracic Surgery, Sun Yat‐sen University Cancer Center, Guangzhou, China. The patients' demographic, pathological, preoperative and cancer outcome data were obtained from medical records. These data were reviewed and analyzed using life table, Kaplan–Meier analysis and multivariate Cox regression. A significant reduction in 3‐ and 5‐year survival rates was observed in smokers with lymph node‐negative ESCC compared with those in non‐smokers. The 3‐ and 5‐year survival rates were 54% and 46% for smokers, and 67% and 64% for non‐drinkers, respectively (P < 0.05). Multivariate Cox analysis revealed that smoking was an independent prognostic factor (P = 0.008, hazard ratio = 1.404). Both log‐rank test (P = 0.065) and multivariate analysis (P = 0.091) showed no significant difference between the survival rates of light and heavy smokers. Prediagnostic smoking is an independent prognostic factor for patients with lymph node‐negative ESCC, but the dose–response relationship needs further investigation.</description><subject>Adult</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>China</subject><subject>Dose-Response Relationship, Drug</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Original</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Survival Rate</subject><issn>1347-9032</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFOGzEQhq2KqkDaAy-AfOWwib12dtcXJBRRqBSpldqeLa89uzHs2oudpMqNR-gz9kkwWYjKAV9mNPP5G-lH6IySKU1vplWc0pwQ8gGdUMZFVhJSHO37MhOE5cfoNMY7QljBBf-EjvNcUFYwfoLWPwIYq1rn49pqHHt_b12LlTN4SCM_QFBruwUcN2Frt6rD1uFu1w8r7LyBf49_HbQjAdEPK9VuIo4PG9X71GjoOqxV0Nb5XuEhgeDW8TP62KguwpeXOkG_v17_Wtxmy-833xZXy0xzJkhWlWB4DnVTs8JorjnJDTdFkQMYU2rSwJyBqUWlKt6wks7nVS0KUmnKuaF1wybocvQOm7oHo9PtoDo5BNursJNeWfl24-xKtn4ry2IuqCiT4GIU6OBjDNAc_lIin6OXKXq5jz6x5_8fO5CvWSdgNgJ_bAe7901ycfVzVD4BtrWUBg</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Lin, Yongbin</creator><creator>Su, Xiaodong</creator><creator>Su, Hongyu</creator><creator>Lin, Peng</creator><creator>Long, Hao</creator><creator>Zhang, Lanjun</creator><creator>Fu, Jianhua</creator><creator>Rong, Tiehua</creator><creator>Tan, Zihui</creator><creator>Meng, Yuqi</creator><creator>Ma, Guowei</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201211</creationdate><title>Prediagnostic smoking and postoperative survival in lymph node‐negative esophagus squamous cell carcinoma patients</title><author>Lin, Yongbin ; Su, Xiaodong ; Su, Hongyu ; Lin, Peng ; Long, Hao ; Zhang, Lanjun ; Fu, Jianhua ; Rong, Tiehua ; Tan, Zihui ; Meng, Yuqi ; Ma, Guowei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4390-87ed42ebfb36dc4c402d4d662eedd7c0fe53edb98a84f371558b9608c144d1bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>China</topic><topic>Dose-Response Relationship, Drug</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Original</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yongbin</creatorcontrib><creatorcontrib>Su, Xiaodong</creatorcontrib><creatorcontrib>Su, Hongyu</creatorcontrib><creatorcontrib>Lin, Peng</creatorcontrib><creatorcontrib>Long, Hao</creatorcontrib><creatorcontrib>Zhang, Lanjun</creatorcontrib><creatorcontrib>Fu, Jianhua</creatorcontrib><creatorcontrib>Rong, Tiehua</creatorcontrib><creatorcontrib>Tan, Zihui</creatorcontrib><creatorcontrib>Meng, Yuqi</creatorcontrib><creatorcontrib>Ma, Guowei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lin, Yongbin</au><au>Su, Xiaodong</au><au>Su, Hongyu</au><au>Lin, Peng</au><au>Long, Hao</au><au>Zhang, Lanjun</au><au>Fu, Jianhua</au><au>Rong, Tiehua</au><au>Tan, Zihui</au><au>Meng, Yuqi</au><au>Ma, Guowei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnostic smoking and postoperative survival in lymph node‐negative esophagus squamous cell carcinoma patients</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2012-11</date><risdate>2012</risdate><volume>103</volume><issue>11</issue><spage>1985</spage><epage>1988</epage><pages>1985-1988</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>Smoking is well known as a risk factor for esophageal cancer, but controversial as a prognostic factor. Moreover, evidence is scarce that a dose–response relationship exists. We conducted a retrospective study on the effect and dose–response relationship of prediagnostic smoking on the postoperative disease‐specific survival of patients with lymph node‐negative esophageal squamous cell carcinoma (ESCC). We enrolled 643 patients with lymph node‐negative ESCC who had undergone esophagectomy between 1990 and 2005 at the Department of Thoracic Surgery, Sun Yat‐sen University Cancer Center, Guangzhou, China. The patients' demographic, pathological, preoperative and cancer outcome data were obtained from medical records. These data were reviewed and analyzed using life table, Kaplan–Meier analysis and multivariate Cox regression. A significant reduction in 3‐ and 5‐year survival rates was observed in smokers with lymph node‐negative ESCC compared with those in non‐smokers. The 3‐ and 5‐year survival rates were 54% and 46% for smokers, and 67% and 64% for non‐drinkers, respectively (P < 0.05). Multivariate Cox analysis revealed that smoking was an independent prognostic factor (P = 0.008, hazard ratio = 1.404). Both log‐rank test (P = 0.065) and multivariate analysis (P = 0.091) showed no significant difference between the survival rates of light and heavy smokers. Prediagnostic smoking is an independent prognostic factor for patients with lymph node‐negative ESCC, but the dose–response relationship needs further investigation.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>22913634</pmid><doi>10.1111/cas.12000</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1347-9032 |
| ispartof | Cancer science, 2012-11, Vol.103 (11), p.1985-1988 |
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| subjects | Adult Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery China Dose-Response Relationship, Drug Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagectomy - methods Female Follow-Up Studies Humans Kaplan-Meier Estimate Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - pathology Male Middle Aged Multivariate Analysis Original Postoperative Period Prognosis Retrospective Studies Smoking - adverse effects Smoking - epidemiology Survival Rate |
| title | Prediagnostic smoking and postoperative survival in lymph node‐negative esophagus squamous cell carcinoma patients |
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