Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model

Pediatric cancer treatment often involves chemotherapy and radiation, where off-target effects can include skeletal muscle decline. The effect of such treatments on juvenile skeletal muscle growth has yet to be investigated. We employed a small animal irradiator to administer fractionated hindlimb i...

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Veröffentlicht in:	Scientific reports 2020-11, Vol.10 (1), p.19501, Article 19501
Hauptverfasser:	Paris, Nicole D., Kallenbach, Jacob G., Bachman, John F., Blanc, Roméo S., Johnston, Carl J., Hernady, Eric, Williams, Jacqueline P., Chakkalakal, Joe V.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/136/1425 631/136/532 631/136/7 631/136/83 631/532 631/532/2118 631/532/2439 631/532/7 631/67 631/67/1059 631/67/1798 631/67/2332 631/67/70 Aging Animals Antineoplastic Agents, Phytogenic - pharmacology Cancer therapies Cell Line, Tumor Chemoradiotherapy Chemoradiotherapy - adverse effects Chemotherapy Disease Models, Animal Dose Fractionation, Radiation Hindlimb - drug effects Hindlimb - pathology Hindlimb - radiation effects Humanities and Social Sciences Hypertrophy Male Mice, Inbred C57BL multidisciplinary Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - pathology Muscle Fibers, Skeletal - radiation effects Musculoskeletal system Pediatrics Radiation Rhabdomyosarcoma Rhabdomyosarcoma - therapy Rotarod Performance Test Science Science (multidisciplinary) Skeletal muscle Transplantation, Isogeneic Tumors Vincristine Vincristine - pharmacology
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