Peroxisome proliferator‐activated receptor‐γ activation inhibits hepatocellular carcinoma cell invasion by upregulating plasminogen activator inhibitor‐1

The peroxisome proliferator‐activated receptor‐γ (PPARγ) is a ligand‐activated transcription factor belonging to the nuclear receptor superfamily. Peroxisome proliferator‐activated receptor‐γ ligands can inhibit cell growth and increase apoptosis of cancer cell lines, suggesting a potential role for...

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Veröffentlicht in:	Cancer science 2013-06, Vol.104 (6), p.672-680
Hauptverfasser:	Pang, Xiaojuan, Wei, Yinna, Zhang, Ya, Zhang, Minyue, Lu, Yan, Shen, Pingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Electrophoretic Mobility Shift Assay Estradiol Estrogens - pharmacology Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Neoplasm Invasiveness - pathology Original Plasminogen Activator Inhibitor 1 - metabolism Plasminogen Activator Inhibitor 1 - pharmacology PPAR gamma - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Up-Regulation
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