Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis
Cyclin F, capable of forming Skp1‐Cul1‐F‐box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. Cyclin F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression and significance in cancer remain ob...
Gespeichert in:
| Veröffentlicht in: | Cancer science 2013-04, Vol.104 (4), p.508-515 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 515 |
|---|---|
| container_issue | 4 |
| container_start_page | 508 |
| container_title | Cancer science |
| container_volume | 104 |
| creator | Fu, Jia Qiu, Huijuan Cai, Muyan Pan, Yinghua Cao, Yun Liu, Lili Yun, Jingping Zhang, Chris Zhiyi |
| description | Cyclin F, capable of forming Skp1‐Cul1‐F‐box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. Cyclin F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression and significance in cancer remain obscure. In this study, we showed that cyclin F was noticeably decreased in 16 pairs of tissue samples of hepatocellular carcinoma (HCC) compared to paracarcinoma tissues, at both mRNA and protein levels. Immunohistochemical staining data revealed that in 71.8% (176/245) of HCC cases, cyclin F expression in tumor tissue was much lower than that in nontumorous tissue. Low cyclin F expression, defined by receiver operating characteristic curve analysis, was present in 69.0% of HCC patients. Low expression of cyclin F was significantly correlated with tumor size, clinical stage, serum alpha‐fetoprotein level and tumor multiplicity. Further study showed that cyclin F expression was reversely associated with tumor differentiation in HCC. Kaplan–Meier analysis indicated that low cyclin F expression was related to poor overall survival and recurrence‐free survival. The prognostic impact of cyclin F was further confirmed by stratified survival analysis. Importantly, multivariate analysis revealed that low cyclin F expression was an independent poor prognostic marker for overall survival. We conclude that cyclin F is downregulated in HCC and is a promising prognostic marker for patients suffering from this deadly disease. |
| doi_str_mv | 10.1111/cas.12100 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7657186</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1319622809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4720-b437af0c36e6f8545d42881535772c07e3a7c3a4981c19135b8758758bdfffc83</originalsourceid><addsrcrecordid>eNp1kctKxDAUhoMo3he-gGSpi2oubdNuBBm8wYALdR1O08SJdJKatI7z9mYcFV0YAkk4H9855EfoiJIzmta5gnhGGSVkA-1SnteZIKTc_LyLrCac7aC9GF8I4WVe59toh3FOCkbELgpTv8BqqTrr8DXW733QMVrvcHrPdA-DV7rrxg4CVhCUdX4OGGL0ysKgI17YYYZ77wNurTE6aDekwkoArsWjM_DmAzSdxn3wz85HGw_QloEu6sOvcx89XV89Tm6z6f3N3eRymqlcMJI1ORdgiOKlLk1V5EWbs6qiBS-EYIoIzUEoDnldUUVryoumEsVqN60xRlV8H12svf3YzHWr0mgBOtkHO4ewlB6s_Ftxdiaf_ZsUZSFoVSbByZcg-NdRx0HObVx9Bzjtxygpp3XJWEXqhJ6uURV8jEGbnzaUyFVGMmUkPzNK7PHvuX7I71AScL4GFrbTy_9NcnL5sFZ-ANXGnh4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1319622809</pqid></control><display><type>article</type><title>Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis</title><source>Wiley Open Access</source><creator>Fu, Jia ; Qiu, Huijuan ; Cai, Muyan ; Pan, Yinghua ; Cao, Yun ; Liu, Lili ; Yun, Jingping ; Zhang, Chris Zhiyi</creator><creatorcontrib>Fu, Jia ; Qiu, Huijuan ; Cai, Muyan ; Pan, Yinghua ; Cao, Yun ; Liu, Lili ; Yun, Jingping ; Zhang, Chris Zhiyi</creatorcontrib><description>Cyclin F, capable of forming Skp1‐Cul1‐F‐box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. Cyclin F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression and significance in cancer remain obscure. In this study, we showed that cyclin F was noticeably decreased in 16 pairs of tissue samples of hepatocellular carcinoma (HCC) compared to paracarcinoma tissues, at both mRNA and protein levels. Immunohistochemical staining data revealed that in 71.8% (176/245) of HCC cases, cyclin F expression in tumor tissue was much lower than that in nontumorous tissue. Low cyclin F expression, defined by receiver operating characteristic curve analysis, was present in 69.0% of HCC patients. Low expression of cyclin F was significantly correlated with tumor size, clinical stage, serum alpha‐fetoprotein level and tumor multiplicity. Further study showed that cyclin F expression was reversely associated with tumor differentiation in HCC. Kaplan–Meier analysis indicated that low cyclin F expression was related to poor overall survival and recurrence‐free survival. The prognostic impact of cyclin F was further confirmed by stratified survival analysis. Importantly, multivariate analysis revealed that low cyclin F expression was an independent poor prognostic marker for overall survival. We conclude that cyclin F is downregulated in HCC and is a promising prognostic marker for patients suffering from this deadly disease.</description><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/cas.12100</identifier><identifier>PMID: 23305207</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biomarkers, Tumor - metabolism ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Cell Differentiation ; Cyclins - metabolism ; Down-Regulation ; Female ; Humans ; Liver Neoplasms - metabolism ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Male ; Middle Aged ; Original ; Prognosis ; Young Adult</subject><ispartof>Cancer science, 2013-04, Vol.104 (4), p.508-515</ispartof><rights>2013 Japanese Cancer Association</rights><rights>2013 Japanese Cancer Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4720-b437af0c36e6f8545d42881535772c07e3a7c3a4981c19135b8758758bdfffc83</citedby><cites>FETCH-LOGICAL-c4720-b437af0c36e6f8545d42881535772c07e3a7c3a4981c19135b8758758bdfffc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657186/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657186/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11543,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcas.12100$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23305207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Jia</creatorcontrib><creatorcontrib>Qiu, Huijuan</creatorcontrib><creatorcontrib>Cai, Muyan</creatorcontrib><creatorcontrib>Pan, Yinghua</creatorcontrib><creatorcontrib>Cao, Yun</creatorcontrib><creatorcontrib>Liu, Lili</creatorcontrib><creatorcontrib>Yun, Jingping</creatorcontrib><creatorcontrib>Zhang, Chris Zhiyi</creatorcontrib><title>Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Cyclin F, capable of forming Skp1‐Cul1‐F‐box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. Cyclin F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression and significance in cancer remain obscure. In this study, we showed that cyclin F was noticeably decreased in 16 pairs of tissue samples of hepatocellular carcinoma (HCC) compared to paracarcinoma tissues, at both mRNA and protein levels. Immunohistochemical staining data revealed that in 71.8% (176/245) of HCC cases, cyclin F expression in tumor tissue was much lower than that in nontumorous tissue. Low cyclin F expression, defined by receiver operating characteristic curve analysis, was present in 69.0% of HCC patients. Low expression of cyclin F was significantly correlated with tumor size, clinical stage, serum alpha‐fetoprotein level and tumor multiplicity. Further study showed that cyclin F expression was reversely associated with tumor differentiation in HCC. Kaplan–Meier analysis indicated that low cyclin F expression was related to poor overall survival and recurrence‐free survival. The prognostic impact of cyclin F was further confirmed by stratified survival analysis. Importantly, multivariate analysis revealed that low cyclin F expression was an independent poor prognostic marker for overall survival. We conclude that cyclin F is downregulated in HCC and is a promising prognostic marker for patients suffering from this deadly disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Differentiation</subject><subject>Cyclins - metabolism</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Prognosis</subject><subject>Young Adult</subject><issn>1347-9032</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMo3he-gGSpi2oubdNuBBm8wYALdR1O08SJdJKatI7z9mYcFV0YAkk4H9855EfoiJIzmta5gnhGGSVkA-1SnteZIKTc_LyLrCac7aC9GF8I4WVe59toh3FOCkbELgpTv8BqqTrr8DXW733QMVrvcHrPdA-DV7rrxg4CVhCUdX4OGGL0ysKgI17YYYZ77wNurTE6aDekwkoArsWjM_DmAzSdxn3wz85HGw_QloEu6sOvcx89XV89Tm6z6f3N3eRymqlcMJI1ORdgiOKlLk1V5EWbs6qiBS-EYIoIzUEoDnldUUVryoumEsVqN60xRlV8H12svf3YzHWr0mgBOtkHO4ewlB6s_Ftxdiaf_ZsUZSFoVSbByZcg-NdRx0HObVx9Bzjtxygpp3XJWEXqhJ6uURV8jEGbnzaUyFVGMmUkPzNK7PHvuX7I71AScL4GFrbTy_9NcnL5sFZ-ANXGnh4</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Fu, Jia</creator><creator>Qiu, Huijuan</creator><creator>Cai, Muyan</creator><creator>Pan, Yinghua</creator><creator>Cao, Yun</creator><creator>Liu, Lili</creator><creator>Yun, Jingping</creator><creator>Zhang, Chris Zhiyi</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201304</creationdate><title>Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis</title><author>Fu, Jia ; Qiu, Huijuan ; Cai, Muyan ; Pan, Yinghua ; Cao, Yun ; Liu, Lili ; Yun, Jingping ; Zhang, Chris Zhiyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4720-b437af0c36e6f8545d42881535772c07e3a7c3a4981c19135b8758758bdfffc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Differentiation</topic><topic>Cyclins - metabolism</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Prognosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Jia</creatorcontrib><creatorcontrib>Qiu, Huijuan</creatorcontrib><creatorcontrib>Cai, Muyan</creatorcontrib><creatorcontrib>Pan, Yinghua</creatorcontrib><creatorcontrib>Cao, Yun</creatorcontrib><creatorcontrib>Liu, Lili</creatorcontrib><creatorcontrib>Yun, Jingping</creatorcontrib><creatorcontrib>Zhang, Chris Zhiyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fu, Jia</au><au>Qiu, Huijuan</au><au>Cai, Muyan</au><au>Pan, Yinghua</au><au>Cao, Yun</au><au>Liu, Lili</au><au>Yun, Jingping</au><au>Zhang, Chris Zhiyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2013-04</date><risdate>2013</risdate><volume>104</volume><issue>4</issue><spage>508</spage><epage>515</epage><pages>508-515</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>Cyclin F, capable of forming Skp1‐Cul1‐F‐box protein ubiquitin ligase complex, is implicated in controlling centrosome duplication and preventing genome instability. Cyclin F oscillates during cell cycle with a similar pattern to cyclin A. However, its expression and significance in cancer remain obscure. In this study, we showed that cyclin F was noticeably decreased in 16 pairs of tissue samples of hepatocellular carcinoma (HCC) compared to paracarcinoma tissues, at both mRNA and protein levels. Immunohistochemical staining data revealed that in 71.8% (176/245) of HCC cases, cyclin F expression in tumor tissue was much lower than that in nontumorous tissue. Low cyclin F expression, defined by receiver operating characteristic curve analysis, was present in 69.0% of HCC patients. Low expression of cyclin F was significantly correlated with tumor size, clinical stage, serum alpha‐fetoprotein level and tumor multiplicity. Further study showed that cyclin F expression was reversely associated with tumor differentiation in HCC. Kaplan–Meier analysis indicated that low cyclin F expression was related to poor overall survival and recurrence‐free survival. The prognostic impact of cyclin F was further confirmed by stratified survival analysis. Importantly, multivariate analysis revealed that low cyclin F expression was an independent poor prognostic marker for overall survival. We conclude that cyclin F is downregulated in HCC and is a promising prognostic marker for patients suffering from this deadly disease.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>23305207</pmid><doi>10.1111/cas.12100</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1347-9032 |
| ispartof | Cancer science, 2013-04, Vol.104 (4), p.508-515 |
| issn | 1347-9032 1349-7006 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7657186 |
| source | Wiley Open Access |
| subjects | Adolescent Adult Aged Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Differentiation Cyclins - metabolism Down-Regulation Female Humans Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Male Middle Aged Original Prognosis Young Adult |
| title | Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T20%3A27%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20cyclin%20F%20expression%20in%20hepatocellular%20carcinoma%20associates%20with%20poor%20differentiation%20and%20unfavorable%20prognosis&rft.jtitle=Cancer%20science&rft.au=Fu,%20Jia&rft.date=2013-04&rft.volume=104&rft.issue=4&rft.spage=508&rft.epage=515&rft.pages=508-515&rft.issn=1347-9032&rft.eissn=1349-7006&rft_id=info:doi/10.1111/cas.12100&rft_dat=%3Cproquest_24P%3E1319622809%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1319622809&rft_id=info:pmid/23305207&rfr_iscdi=true |