A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis

Plasma fibrinogen molecules comprise 2 copies of Aα, Bβ, and γ chains folded into a hexameric protein. A minor fibrinogen isoform with an extended Aα chain (AαE) is more abundant in newborn human blood than in adults. Larval zebrafish produce predominantly AαE-containing fibrinogen, but its function...

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Veröffentlicht in:	Blood advances 2020-11, Vol.4 (21), p.5480-5491
Hauptverfasser:	Freire, Cristina, Fish, Richard J., Vilar, Rui, Di Sanza, Corinne, Grzegorski, Steven J., Richter, Catherine E., Shavit, Jordan A., Neerman-Arbez, Marguerite
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fibrinogen - genetics Hemostasis Hemostatics Thrombosis and Hemostasis Venous Thrombosis Zebrafish
Online-Zugang:	Volltext
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