MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis

Mitsugumin 53 (MG53) is a tripartite motif family protein that has been reported to attenuate injury via membrane repair in different organs. Contrast-induced acute kidney injury (CI-AKI) is a common complication caused by the administration of iodinated contrast media (CM). While the cytotoxicity i...

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Veröffentlicht in:	Acta pharmacologica Sinica 2020-11, Vol.41 (11), p.1457-1464
Hauptverfasser:	Liu, Chao, Hu, Yun-hui, Han, Yu, Wang, Yong-bin, Zhang, Yan, Zhang, Xiao-qun, He, Duo-fen, Ren, Hong-mei, Liu, Yu-kai, Wang, Hong-yong, Tan, Tao, Lin, Pei-hui, Li, Hai-chang, Rovin, Brad H., Ma, Jian-jie, Zeng, Chun-yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cell death Cell Membrane - drug effects Cell Membrane - metabolism Cell membranes Contrast media Creatinine Cytotoxicity Epithelial Cells Female Humans Immunology Internal Medicine Iohexol - analogs & derivatives Kidney - pathology Kidney Tubules, Proximal - cytology Kidneys Male Medical Microbiology Pharmacology/Toxicology Phosphatidylserine Phosphatidylserines - metabolism Protective Agents - metabolism Protective Agents - therapeutic use Rats, Inbred WKY Rats, Sprague-Dawley Recombinant Proteins - metabolism Recombinant Proteins - therapeutic use Tripartite Motif Proteins - metabolism Tripartite Motif Proteins - therapeutic use Urea Vaccine
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