Capturing the mammalian Hippo: Elucidating its role in cancer

The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self‐renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue archit...

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Veröffentlicht in:	Cancer science 2013-10, Vol.104 (10), p.1271-1277
Hauptverfasser:	Nishio, Miki, Otsubo, Kohei, Maehama, Tomohiko, Mimori, Koshi, Suzuki, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cell Movement - physiology Cell Polarity - physiology Cell Transformation, Neoplastic Drosophila Proteins - physiology Enzyme Activation Epithelial-Mesenchymal Transition - physiology Humans Intracellular Signaling Peptides and Proteins - physiology Mammals - metabolism Mice Mice, Mutant Strains Neoplasm Proteins - physiology Neoplasms - enzymology Oncogenes Protein-Serine-Threonine Kinases - physiology Review Signal Transduction - physiology Species Specificity Stem Cells - physiology
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