Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of blood vessels that regulates blood-cell traffic as well as the maintenance and function of haematopoietic stem and progenitor cells. Here, we report the design and in vivo performance of systemically injected lipid...

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Veröffentlicht in:	Nature biomedical engineering 2020-11, Vol.4 (11), p.1076-1089
Hauptverfasser:	Krohn-Grimberghe, Marvin, Mitchell, Michael J., Schloss, Maximilian J., Khan, Omar F., Courties, Gabriel, Guimaraes, Pedro P. G., Rohde, David, Cremer, Sebastian, Kowalski, Piotr S., Sun, Yuan, Tan, Mingchee, Webster, Jamie, Wang, Karin, Iwamoto, Yoshiko, Schmidt, Stephen P., Wojtkiewicz, Gregory R., Nayar, Ribhu, Frodermann, Vanessa, Hulsmans, Maarten, Chung, Amanda, Hoyer, Friedrich Felix, Swirski, Filip K., Langer, Robert, Anderson, Daniel G., Nahrendorf, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/63 639/925/350 692/4019 692/699/1541 692/699/249 Animals Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Blood vessels Bone healing Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cardiovascular diseases Cells, Cultured Congestive heart failure Coronary artery disease Disease Models, Animal Drug Delivery Systems - methods Encapsulation Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Gene silencing Gene Silencing - drug effects Genes Healing Heart attacks Hematopoietic stem cells Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Leukocytes Lipids Mice, Inbred C57BL Monocyte chemoattractant protein 1 Monocytes Myocardial infarction Myocardial Infarction - prevention & control Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Polymers Progenitor cells Proteins Ribonucleic acid RNA RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry RNA-mediated interference SDF-1 protein siRNA Stem Cell Niche - genetics Stem cells Therapeutic applications
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