MicroRNA-143 sensitizes acute myeloid leukemia cells to cytarabine via targeting ATG7- and ATG2B-dependent autophagy

Targeting autophagy holds promise to enhance chemosensitivity in acute myeloid leukemia (AML). MicroRNA-143 (miR-143) has been found to suppress autophagy, however, it is not clear whether miR-143 augments cytarabine cytotoxicity in AML. Here, we report that cytarabine treatment reduces miR-143 expr...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-10, Vol.12 (20), p.20111-20126
Hauptverfasser:	Zhang, Hao, Kang, Jianmin, Liu, Ling, Chen, Lulu, Ren, Saisai, Tao, Yanling
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Apoptosis - drug effects Autophagy - drug effects Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Caspase 3 - metabolism Caspase 9 - metabolism Cytarabine - pharmacology Dose-Response Relationship, Drug Gene Expression Regulation, Leukemic HL-60 Cells Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology MicroRNAs - genetics MicroRNAs - metabolism Research Paper Signal Transduction U937 Cells Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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