Molecular Imaging of Apoptosis in Atherosclerosis by Targeting Cell Membrane Phospholipid Asymmetry

Apoptosis in atherosclerotic lesions contributes to plaque vulnerability by lipid core enlargement and fibrous cap attenuation. Apoptosis is associated with exteriorization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell membrane. Although PS-avid radiolabeled annexin-V has...

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Veröffentlicht in:	Journal of the American College of Cardiology 2020-10, Vol.76 (16), p.1862-1874
Hauptverfasser:	Chaudhry, Farhan, Kawai, Hideki, Johnson, Kipp W., Narula, Navneet, Shekhar, Aditya, Chaudhry, Fayzan, Nakahara, Takehiro, Tanimoto, Takashi, Kim, Dongbin, Adapoe, Matthew K.M.Y., Blankenberg, Francis G., Mattis, Jeffrey A., Pak, Koon Y., Levy, Phillip D., Ozaki, Yukio, Arbustini, Eloisa, Strauss, H. William, Petrov, Artiom, Fuster, Valentin, Narula, Jagat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals annexin-V Apoptosis - physiology Atherosclerosis - diagnostic imaging Atherosclerosis - etiology Atherosclerosis - metabolism Bacteriocins - metabolism cell death Cell Membrane - metabolism Cell Membrane - pathology Diet, High-Fat - adverse effects duramycin Humans Male Molecular Imaging - methods Peptides - metabolism Phospholipids - metabolism Rabbits radionuclide imaging Radionuclide Imaging - methods vulnerable plaques
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