Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs

Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. However, the mechanism by which morphine causes these effects and how they sometimes...

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Veröffentlicht in:	Clinical epigenetics 2020-11, Vol.12 (1), p.170-170, Article 170
Hauptverfasser:	Muñoa-Hoyos, Iraia, Halsall, John A, Araolaza, Manu, Ward, Carl, Garcia, Idoia, Urizar-Arenaza, Itziar, Gianzo, Marta, Garcia, Paloma, Turner, Bryan, Subirán, Nerea
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analysis Apoptosis Binding sites Cell cycle Cell division Chromatin Embryo cells Embryonic development Embryonic stem cells Embryos Epigenetic inheritance Epigenetics Gene expression Genes Genomes Genomics Histones Metabolism Morphine Morphology Ontology Physiological aspects Placenta Polycomb group proteins Promoters Proteins Stem cell transplantation Stem cells Transcription Transcription (Genetics)
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