Bisphosphonates and risk of cancers: a systematic review and meta-analysis
Background It is unclear whether bisphosphonates are associated with risk of cancers. Therefore, this meta-analysis aimed to evaluate the effect of bisphosphonates on overall cancers. Methods A search in Pubmed, Embase, Cochrane Library and Web of Science databases was conducted, from the inception...
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| Veröffentlicht in: | British journal of cancer 2020-11, Vol.123 (10), p.1570-1581 |
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| creator | Li, Yuan-Yuan Gao, Li-Jie Zhang, Yu-Xue Liu, Shu-Juan Cheng, Shuo Liu, Yu-Peng Jia, Cun-Xian |
| description | Background
It is unclear whether bisphosphonates are associated with risk of cancers. Therefore, this meta-analysis aimed to evaluate the effect of bisphosphonates on overall cancers.
Methods
A search in Pubmed, Embase, Cochrane Library and Web of Science databases was conducted, from the inception date of each resource to September 26, 2019. The summarised effect estimates with 95% CIs were calculated using a random-effect model. Heterogeneity and publication bias were explored.
Results
Thirty-four articles were included in this study (4,508,261 participants; 403,196 cases). The results revealed that bisphosphonates significantly decreased the risk of colorectal cancer (RR = 0.89, 95% CI: 0.81–0.98), breast cancer (RR = 0.87, 95% CI: 0.82–0.93) and endometrial cancer (RR = 0.75, 95% CI: 0.61–0.94), but no significant association was observed in all-cause cancer. Furthermore, nitrogen-containing bisphosphonates only had protective effects both on breast cancer (RR = 0.94, 95% CI: 0.90–0.99) and endometrial cancer (RR = 0.70, 95% CI: 0.54–0.92). Non-nitrogen-containing bisphosphonates tended to increase the risk of liver cancer (RR = 2.14, 95% CI: 1.23–3.72) and pancreas cancer (RR = 1.75, 95% CI: 1.32–2.33).
Conclusion
Bisphosphonates are significantly associated with risk reduction of colorectal, breast and endometrial cancer, especially nitrogen-containing bisphosphonates. It should be noted that non-nitrogen-containing bisphosphonates might increase the risk of liver and pancreas cancer. Large prospective cohort studies are needed to find the causal association between bisphosphonates and risk of cancers. |
| doi_str_mv | 10.1038/s41416-020-01043-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7652831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471553657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-ef6beaa7e618d6f143e52302987124c5141312910c20ff9ec10aeedacb3ffad03</originalsourceid><addsrcrecordid>eNp9kUlvFDEQhS0EIpPAH-CAWuLCxVDlpRcOSBARFkXiAmfL4y4nDr0Mrp6g-fd4MiEsBw4lq1RfvfLTE-IJwgsE3b5kgwZrCQokIBgtu3tihVYria1q7osVADQSOgVH4pj5qrQdtM1DcaRVB4jarMSnt4k3l_O-Jr8QV37qq5z4WzXHKvgpUOZXla94xwuNfkmhynSd6McNONLipZ_8sOPEj8SD6Aemx7fvifh69u7L6Qd5_vn9x9M35zKYxiySYr0m7xuqse3riEaTVRpU1zaoTLDFk0bVIQQFMXYUEDxR78Nax-h70Cfi9UF3s12P1AealuwHt8lp9HnnZp_c35MpXbqL-do1tVWtxiLw_FYgz9-3xIsbEwcaBj_RvGWnjEFlW233t579g17N21wM76kGrdW1bQqlDlTIM3OmePcZBLePyh2iciUqdxOV68rS0z9t3K38yqYA-gBwGU0XlH_f_o_sT0qkn48</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471553657</pqid></control><display><type>article</type><title>Bisphosphonates and risk of cancers: a systematic review and meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Li, Yuan-Yuan ; Gao, Li-Jie ; Zhang, Yu-Xue ; Liu, Shu-Juan ; Cheng, Shuo ; Liu, Yu-Peng ; Jia, Cun-Xian</creator><creatorcontrib>Li, Yuan-Yuan ; Gao, Li-Jie ; Zhang, Yu-Xue ; Liu, Shu-Juan ; Cheng, Shuo ; Liu, Yu-Peng ; Jia, Cun-Xian</creatorcontrib><description>Background
It is unclear whether bisphosphonates are associated with risk of cancers. Therefore, this meta-analysis aimed to evaluate the effect of bisphosphonates on overall cancers.
Methods
A search in Pubmed, Embase, Cochrane Library and Web of Science databases was conducted, from the inception date of each resource to September 26, 2019. The summarised effect estimates with 95% CIs were calculated using a random-effect model. Heterogeneity and publication bias were explored.
Results
Thirty-four articles were included in this study (4,508,261 participants; 403,196 cases). The results revealed that bisphosphonates significantly decreased the risk of colorectal cancer (RR = 0.89, 95% CI: 0.81–0.98), breast cancer (RR = 0.87, 95% CI: 0.82–0.93) and endometrial cancer (RR = 0.75, 95% CI: 0.61–0.94), but no significant association was observed in all-cause cancer. Furthermore, nitrogen-containing bisphosphonates only had protective effects both on breast cancer (RR = 0.94, 95% CI: 0.90–0.99) and endometrial cancer (RR = 0.70, 95% CI: 0.54–0.92). Non-nitrogen-containing bisphosphonates tended to increase the risk of liver cancer (RR = 2.14, 95% CI: 1.23–3.72) and pancreas cancer (RR = 1.75, 95% CI: 1.32–2.33).
Conclusion
Bisphosphonates are significantly associated with risk reduction of colorectal, breast and endometrial cancer, especially nitrogen-containing bisphosphonates. It should be noted that non-nitrogen-containing bisphosphonates might increase the risk of liver and pancreas cancer. Large prospective cohort studies are needed to find the causal association between bisphosphonates and risk of cancers.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-020-01043-9</identifier><identifier>PMID: 32901134</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/2195 ; 692/699/67/2195 ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Bisphosphonates ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Cancer Research ; Colonic Neoplasms - epidemiology ; Colonic Neoplasms - etiology ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - etiology ; Cytoprotection - drug effects ; Diphosphonates - chemistry ; Diphosphonates - therapeutic use ; Drug Resistance ; Endometrial cancer ; Endometrial Neoplasms - epidemiology ; Endometrial Neoplasms - etiology ; Endometrium ; Epidemiology ; Female ; Humans ; Liver cancer ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Male ; Meta-analysis ; Middle Aged ; Molecular Medicine ; Neoplasms - epidemiology ; Neoplasms - etiology ; Nitrogen ; Nitrogen Compounds - chemistry ; Nitrogen Compounds - therapeutic use ; Oncology ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - etiology ; Prevalence ; Risk Factors</subject><ispartof>British journal of cancer, 2020-11, Vol.123 (10), p.1570-1581</ispartof><rights>The Author(s), under exclusive licence to Cancer Research UK 2020</rights><rights>The Author(s), under exclusive licence to Cancer Research UK 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ef6beaa7e618d6f143e52302987124c5141312910c20ff9ec10aeedacb3ffad03</citedby><cites>FETCH-LOGICAL-c474t-ef6beaa7e618d6f143e52302987124c5141312910c20ff9ec10aeedacb3ffad03</cites><orcidid>0000-0002-2651-147X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652831/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652831/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32901134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yuan-Yuan</creatorcontrib><creatorcontrib>Gao, Li-Jie</creatorcontrib><creatorcontrib>Zhang, Yu-Xue</creatorcontrib><creatorcontrib>Liu, Shu-Juan</creatorcontrib><creatorcontrib>Cheng, Shuo</creatorcontrib><creatorcontrib>Liu, Yu-Peng</creatorcontrib><creatorcontrib>Jia, Cun-Xian</creatorcontrib><title>Bisphosphonates and risk of cancers: a systematic review and meta-analysis</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background
It is unclear whether bisphosphonates are associated with risk of cancers. Therefore, this meta-analysis aimed to evaluate the effect of bisphosphonates on overall cancers.
Methods
A search in Pubmed, Embase, Cochrane Library and Web of Science databases was conducted, from the inception date of each resource to September 26, 2019. The summarised effect estimates with 95% CIs were calculated using a random-effect model. Heterogeneity and publication bias were explored.
Results
Thirty-four articles were included in this study (4,508,261 participants; 403,196 cases). The results revealed that bisphosphonates significantly decreased the risk of colorectal cancer (RR = 0.89, 95% CI: 0.81–0.98), breast cancer (RR = 0.87, 95% CI: 0.82–0.93) and endometrial cancer (RR = 0.75, 95% CI: 0.61–0.94), but no significant association was observed in all-cause cancer. Furthermore, nitrogen-containing bisphosphonates only had protective effects both on breast cancer (RR = 0.94, 95% CI: 0.90–0.99) and endometrial cancer (RR = 0.70, 95% CI: 0.54–0.92). Non-nitrogen-containing bisphosphonates tended to increase the risk of liver cancer (RR = 2.14, 95% CI: 1.23–3.72) and pancreas cancer (RR = 1.75, 95% CI: 1.32–2.33).
Conclusion
Bisphosphonates are significantly associated with risk reduction of colorectal, breast and endometrial cancer, especially nitrogen-containing bisphosphonates. It should be noted that non-nitrogen-containing bisphosphonates might increase the risk of liver and pancreas cancer. Large prospective cohort studies are needed to find the causal association between bisphosphonates and risk of cancers.</description><subject>631/67/2195</subject><subject>692/699/67/2195</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bisphosphonates</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Cancer Research</subject><subject>Colonic Neoplasms - epidemiology</subject><subject>Colonic Neoplasms - etiology</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Cytoprotection - drug effects</subject><subject>Diphosphonates - chemistry</subject><subject>Diphosphonates - therapeutic use</subject><subject>Drug Resistance</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - epidemiology</subject><subject>Endometrial Neoplasms - etiology</subject><subject>Endometrium</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Nitrogen</subject><subject>Nitrogen Compounds - chemistry</subject><subject>Nitrogen Compounds - therapeutic use</subject><subject>Oncology</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - etiology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUlvFDEQhS0EIpPAH-CAWuLCxVDlpRcOSBARFkXiAmfL4y4nDr0Mrp6g-fd4MiEsBw4lq1RfvfLTE-IJwgsE3b5kgwZrCQokIBgtu3tihVYria1q7osVADQSOgVH4pj5qrQdtM1DcaRVB4jarMSnt4k3l_O-Jr8QV37qq5z4WzXHKvgpUOZXla94xwuNfkmhynSd6McNONLipZ_8sOPEj8SD6Aemx7fvifh69u7L6Qd5_vn9x9M35zKYxiySYr0m7xuqse3riEaTVRpU1zaoTLDFk0bVIQQFMXYUEDxR78Nax-h70Cfi9UF3s12P1AealuwHt8lp9HnnZp_c35MpXbqL-do1tVWtxiLw_FYgz9-3xIsbEwcaBj_RvGWnjEFlW233t579g17N21wM76kGrdW1bQqlDlTIM3OmePcZBLePyh2iciUqdxOV68rS0z9t3K38yqYA-gBwGU0XlH_f_o_sT0qkn48</recordid><startdate>20201110</startdate><enddate>20201110</enddate><creator>Li, Yuan-Yuan</creator><creator>Gao, Li-Jie</creator><creator>Zhang, Yu-Xue</creator><creator>Liu, Shu-Juan</creator><creator>Cheng, Shuo</creator><creator>Liu, Yu-Peng</creator><creator>Jia, Cun-Xian</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2651-147X</orcidid></search><sort><creationdate>20201110</creationdate><title>Bisphosphonates and risk of cancers: a systematic review and meta-analysis</title><author>Li, Yuan-Yuan ; Gao, Li-Jie ; Zhang, Yu-Xue ; Liu, Shu-Juan ; Cheng, Shuo ; Liu, Yu-Peng ; Jia, Cun-Xian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ef6beaa7e618d6f143e52302987124c5141312910c20ff9ec10aeedacb3ffad03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/67/2195</topic><topic>692/699/67/2195</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bisphosphonates</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Cancer Research</topic><topic>Colonic Neoplasms - epidemiology</topic><topic>Colonic Neoplasms - etiology</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - etiology</topic><topic>Cytoprotection - drug effects</topic><topic>Diphosphonates - chemistry</topic><topic>Diphosphonates - therapeutic use</topic><topic>Drug Resistance</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - epidemiology</topic><topic>Endometrial Neoplasms - etiology</topic><topic>Endometrium</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - etiology</topic><topic>Nitrogen</topic><topic>Nitrogen Compounds - chemistry</topic><topic>Nitrogen Compounds - therapeutic use</topic><topic>Oncology</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - epidemiology</topic><topic>Pancreatic Neoplasms - etiology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yuan-Yuan</creatorcontrib><creatorcontrib>Gao, Li-Jie</creatorcontrib><creatorcontrib>Zhang, Yu-Xue</creatorcontrib><creatorcontrib>Liu, Shu-Juan</creatorcontrib><creatorcontrib>Cheng, Shuo</creatorcontrib><creatorcontrib>Liu, Yu-Peng</creatorcontrib><creatorcontrib>Jia, Cun-Xian</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yuan-Yuan</au><au>Gao, Li-Jie</au><au>Zhang, Yu-Xue</au><au>Liu, Shu-Juan</au><au>Cheng, Shuo</au><au>Liu, Yu-Peng</au><au>Jia, Cun-Xian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bisphosphonates and risk of cancers: a systematic review and meta-analysis</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2020-11-10</date><risdate>2020</risdate><volume>123</volume><issue>10</issue><spage>1570</spage><epage>1581</epage><pages>1570-1581</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Background
It is unclear whether bisphosphonates are associated with risk of cancers. Therefore, this meta-analysis aimed to evaluate the effect of bisphosphonates on overall cancers.
Methods
A search in Pubmed, Embase, Cochrane Library and Web of Science databases was conducted, from the inception date of each resource to September 26, 2019. The summarised effect estimates with 95% CIs were calculated using a random-effect model. Heterogeneity and publication bias were explored.
Results
Thirty-four articles were included in this study (4,508,261 participants; 403,196 cases). The results revealed that bisphosphonates significantly decreased the risk of colorectal cancer (RR = 0.89, 95% CI: 0.81–0.98), breast cancer (RR = 0.87, 95% CI: 0.82–0.93) and endometrial cancer (RR = 0.75, 95% CI: 0.61–0.94), but no significant association was observed in all-cause cancer. Furthermore, nitrogen-containing bisphosphonates only had protective effects both on breast cancer (RR = 0.94, 95% CI: 0.90–0.99) and endometrial cancer (RR = 0.70, 95% CI: 0.54–0.92). Non-nitrogen-containing bisphosphonates tended to increase the risk of liver cancer (RR = 2.14, 95% CI: 1.23–3.72) and pancreas cancer (RR = 1.75, 95% CI: 1.32–2.33).
Conclusion
Bisphosphonates are significantly associated with risk reduction of colorectal, breast and endometrial cancer, especially nitrogen-containing bisphosphonates. It should be noted that non-nitrogen-containing bisphosphonates might increase the risk of liver and pancreas cancer. Large prospective cohort studies are needed to find the causal association between bisphosphonates and risk of cancers.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32901134</pmid><doi>10.1038/s41416-020-01043-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2651-147X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2020-11, Vol.123 (10), p.1570-1581 |
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| subjects | 631/67/2195 692/699/67/2195 Aged Biomedical and Life Sciences Biomedicine Bisphosphonates Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - etiology Cancer Research Colonic Neoplasms - epidemiology Colonic Neoplasms - etiology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - etiology Cytoprotection - drug effects Diphosphonates - chemistry Diphosphonates - therapeutic use Drug Resistance Endometrial cancer Endometrial Neoplasms - epidemiology Endometrial Neoplasms - etiology Endometrium Epidemiology Female Humans Liver cancer Liver Neoplasms - epidemiology Liver Neoplasms - etiology Male Meta-analysis Middle Aged Molecular Medicine Neoplasms - epidemiology Neoplasms - etiology Nitrogen Nitrogen Compounds - chemistry Nitrogen Compounds - therapeutic use Oncology Pancreas Pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - etiology Prevalence Risk Factors |
| title | Bisphosphonates and risk of cancers: a systematic review and meta-analysis |
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