Retinoic Acid Sensitivity of Triple-Negative Breast Cancer Cells Characterized by Constitutive Activation of the notch1 Pathway: The Role of Rarβ

Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB-157 and MDA-M...

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Veröffentlicht in:	Cancers 2020-10, Vol.12 (10), p.3027
Hauptverfasser:	Paroni, Gabriela, Zanetti, Adriana, Barzago, Maria Monica, Kurosaki, Mami, Guarrera, Luca, Fratelli, Maddalena, Troiani, Martina, Ubezio, Paolo, Bolis, Marco, Vallerga, Arianna, Biancardi, Federica, Terao, Mineko, Garattini, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cell activation Clinical trials DNA methylation Gene expression Leukemia Ligands Notch1 protein Retinoic acid Secretase Signal transduction Tumors Vitamin A
Online-Zugang:	Volltext
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